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  Thrombolytic treatment of clot embolism in rat - Comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator

Niessen, F., Hilger, T., Hoehn, M., & Hossmann, K.-A. (2002). Thrombolytic treatment of clot embolism in rat - Comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator. Stroke, 33(12), 2999-3005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-DA46-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-DA47-A
Genre: Journal Article

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 Creators:
Niessen, Frank1, Author              
Hilger, Thomas1, Author              
Hoehn, Mathias2, Author              
Hossmann, Konstantin-Alexander1, Author              
Affiliations:
1Konstantin-Alexander Hossmann, Emeriti, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149648              
2In-vivo-NMR, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society, ou_2149666              

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Free keywords: embolism; magnetic resonance imaging; thrombolytic therapy; rats
 Abstract: Copyright 2002 American Heart Association, Inc.
 Abstract: Background and Purpose-We sought to test the hypothesis that intra-arterial recombinant tissue plasminogen activator (rtPA) treatment of thromboembolic stroke is more efficient than intravenous application. Methods-Rats were embolized by intracarotid injection of autologous fibrin-rich blood clots. One hour later rtPA (10 mg/kg) was infused either intravenously (n=8) or intra-arterially (n=8). Control rats (n=8) received intra-arterial infusion of saline. Treatment was monitored by MR perfusion-weighted imaging and apparent diffusion coefficient (ADC) imaging, and outcome was evaluated by comparing incidence of hemorrhages and lesion volumes of ATP and pH. Results-Clot embolism led to a decline of perfusion- weighted imaging signal intensity in the middle cerebral artery territory to <40% of control. Both intra-arterial and intravenous treatment significantly improved blood flow in cerebral cortex but not in caudate putamen. In untreated animals, ATP and pH lesion volumes were 510.3+/-94.5 and 438.6+/-39.2 mm(3) at 7 hours after clot embolism, respectively. Both intravenous and intra-arterial rtPA treatment produced hemorrhagic complications but reduced ATP lesion size to 296.2+/-136.1 and 370.3+/-103.7 mm(3) and reduced pH lesion size to 263.3+/-114.6 and 303.3+/-103.0 mm(3), respectively (P<0.05 for untreated versus treated rats; no difference between intravenous and intra-arterial treatment). ADC imaging revealed that lesion reduction was due to inhibition of infarct growth but not to reversal of primary injury. Conclusions-This study documents reduction of injury by rtPA treatment but does not reveal a difference between intra- arterial and intravenous application. Our data do not support an advantage of intra-arterial thrombolysis.

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Language(s): eng - English
 Dates: 2002-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13142
ISI: 000179827100051
 Degree: -

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Title: Stroke
  Alternative Title : Stroke
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 33 (12) Sequence Number: - Start / End Page: 2999 - 3005 Identifier: ISSN: 0039-2499