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  Single-shot multi-slice T1 mapping at high spatial resolution – Inversion-recovery FLASH with radial undersampling and iterative reconstruction.

Wang, X., Roeloffs, V. B., Merboldt, K. D., Voit, D., Schätz, S., & Frahm, J. (2015). Single-shot multi-slice T1 mapping at high spatial resolution – Inversion-recovery FLASH with radial undersampling and iterative reconstruction. The Open Medical Imaging Journal, 9, 1-8. doi:10.2174/1874347101509010001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-CE49-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-225F-E
Genre: Journal Article

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http://benthamopen.com/ABSTRACT/TOMIJ-9-1 (Publisher version)
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Wang , X., Author
Roeloffs, Volkert Brar1, Author              
Merboldt, K. D.1, Author              
Voit, D.1, Author              
Schätz, Sebastian1, Author              
Frahm, J.1, Author              
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1Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society, ou_578634              

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 Abstract: Purpose: To develop a method for T1 mapping at high spatial resolution and for multiple slices. Methods: The proposed method emerges as a single-shot inversion-recovery experiment which covers the entire spinlattice relaxation process by serial acquisitions of highly undersampled radial FLASH images, either in single-slice or multi-slice mode. Serial image reconstructions are performed in time-reversed order and first involve regularized nonlinear inversion (NLINV) to estimate optimum coil sensitivity profiles. Subsequently, the coil profiles are fixed for the calculation of differently T1-weighted frames and the resulting linear inverse problem is solved by a conjugate gradient (CG) technique. T1 values are obtained by pixelwise fitting with a Deichmann correction modified for multi-slice applications. Results: T1 accuracy was validated for a reference phantom. For human brain, T1 maps were obtained at 0.5 mm resolution for single-slice acquisitions and at 0.75 mm resolution for up to 5 simultaneous slices (5 mm thickness). Corresponding T1 maps of the liver were acquired at 1 mm and 1.5 mm resolution, respectively. All T1 values were in agreement with literature data. Conclusion: Inversion-recovery sequences with highly undersampled radial FLASH images and NLINV/CG reconstruction allow for fast, robust and accurate T1 mapping at high spatial resolution and for multiple slices.

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Language(s): eng - English
 Dates: 2015-04-24
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.2174/1874347101509010001
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Title: The Open Medical Imaging Journal
Source Genre: Journal
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Pages: - Volume / Issue: 9 Sequence Number: - Start / End Page: 1 - 8 Identifier: -