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  Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

Radziuk, D. V., & Möhwald, H. (2015). Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells. Physical Chemistry Chemical Physics, 17(33), 21072-21093. doi:10.1039/C4CP04946B.

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Radziuk, Darya V.1, Author              
Möhwald, Helmuth1, Author              
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1Helmuth Möhwald, Grenzflächen, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863312              

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 Abstract: Single molecule surface enhanced Raman scattering (SM-SERS) is a highly local effect occurring at sharp edges, interparticle junctions and crevices or other geometries with a sharp nanoroughness of plasmonic nanostructures (“hot spots”). The emission of an individual molecule at SM-SERS conditions depends on the local enhancement field of the hot spots, as well as the binding affinity and positioning at a hot spot region. In this regard, the stability of near-field nano-optics at hot spots is critical, particularly in a biological milieu. In this perspective review, we address recent advances in the experimental and theoretical approaches for the successful development of SM-SERS. Significant progress in the understanding of the interaction between the excitation electromagnetic field and the surface plasmon modes at the metallic or metallic/dielectric interface of various curvatures are described. New knowledge on methodological strategies for positioning the analytes for SM-SERS and Raman-assisted SERS or the SERS imaging of live cells has been acquired and displayed. In the framework of the extensive development of SM-SERS as an advancing diagnostic analytical technique, the real-time SERS chemical imaging of intracellular compartments and tracing of individual analytes has been achieved. In this context, we highlight the tremendous potential of SERS chemical imaging as a future prospect in SERS and SM-SERS for the prediction and diagnosis of diseases.

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 Dates: 2015-01-082015
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C4CP04946B
BibTex Citekey: C4CP04946B
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Title: Physical Chemistry Chemical Physics
  Abbreviation : Phys. Chem. Chem. Phys.
Source Genre: Journal
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Publ. Info: Cambridge, England : Royal Society of Chemistry
Pages: - Volume / Issue: 17 (33) Sequence Number: - Start / End Page: 21072 - 21093 Identifier: ISSN: 1463-9076