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Abstract:
The present invention is directed to a method
for continuous production of dihydroartemisinin and also
artemisinin derivatives derived from dihydroartemisinin
by using artemisinin or dihydroartemisinic acid (DHAA)
as starting material as well as to a continuous flow reactor
for producing dihydroartemisinin as well as the artemisinin
derivatives. It was found that the reduction of artemisinin
to dihydroartemisinin in a continuous process requires
a special kind of reactor and a special combination
of reagents comprising a hydride reducing agent, at least
one activator such as an inorganic activator, at least one
solid base, at least one aprotic solvent and at least one
C1-C5 alcohol.
