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  Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

Kopetzki, D., McQuade, D. T., Seeberger, P. H., & Gilmore, K.(2015). Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives.

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 Creators:
Kopetzki, Daniel1, Author              
McQuade, D. Tyler1, Author              
Seeberger, Peter H.2, Author              
Gilmore, Kerry3, Author              
Affiliations:
1Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
3Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              

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 Abstract: The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

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 Dates: 2013-07-152015-01-21
 Publication Status: Published online
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 Identifiers: Patent Application Nr.: EP13176539.8
Patent Publication Nr.: EP2826779
Patent Nr.: WO2015007693
 Degree: -

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