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  Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-1401-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-1402-E
Genre: Patent

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2156857.pdf (Publisher version), 4MB
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 Creators:
Seeberger, Peter H.1, Author              
Martin, Christopher E.2, Author              
Bröcker, Felix3, Author              
Chakkumkal, Anish3, Author              
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
3Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              

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 Abstract: The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1---+3 ) -B-D-Glcp- ( 1---+4) - [a-L-Rhap- ( 1---+3 ] -aD- Glcp- ( 1---+2 ) -a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.

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 Dates: 2011-08-022013-02-07
 Publication Status: Published online
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 Identifiers: Patent Application Nr.: EP20110006355
Patent Publication Nr.: WO2013017254
Patent Nr.: EP2739636
 Degree: -

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