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  Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine
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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-5F76-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-5F77-9
Genre: Patent

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2156984.pdf (Publisher version), 2MB
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 Creators:
Seeberger, Peter H.1, Author              
Oberli, Matthias2, Author              
Hecht, Mary-Lyn2, Author              
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              
2Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              

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 Abstract: The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium difjicile glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)nNHz, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen Clostridium difjicile. In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.

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 Dates: 2011-03-082012-09-13
 Publication Status: Published online
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 Identifiers: Patent Application Nr.: US201161450388P
Patent Publication Nr.: WO2012119769
Patent Nr.: EP2683401
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