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  Aberrant salience is related to reduced reinforcement learning signals and elevated dopamine synthesis capacity in healthy adults

Boehme, R., Deserno, L., Gleich, T., Katthagen, T., Pankow, A., Behr, J., et al. (2015). Aberrant salience is related to reduced reinforcement learning signals and elevated dopamine synthesis capacity in healthy adults. The Journal of Neuroscience, 35(28), 10103-10111. doi:10.1523/JNEUROSCI.0805-15.2015.

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 Creators:
Boehme, Rebecca1, Author
Deserno, Lorenz1, 2, 3, Author           
Gleich, Tobias1, Author
Katthagen, Teresa1, Author
Pankow, Anne1, Author
Behr, Joachim1, 4, 5, Author
Buchert, Ralph1, Author
Roiser, Jonathan6, Author
Heinz, Andreas1, Author
Schlagenhauf, Florian1, 2, Author           
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_1753350              
3Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4Institute for Neurophysiology, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School Brandenburg, Neuruppin, ou_persistent22              
6Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              

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Free keywords: Aberrant salience; Dopamine; Orbitofrontal cortex; Prediction error; Reinforcement learning; Ventral striatum
 Abstract: The striatum is known to play a key role in reinforcement learning, specifically in the encoding of teaching signals such as reward prediction errors (RPEs). It has been proposed that aberrant salience attribution is associated with impaired coding of RPE and heightened dopamine turnover in the striatum, and might be linked to the development of psychotic symptoms. However, the relationship of aberrant salience attribution, RPE coding, and dopamine synthesis capacity has not been directly investigated. Here we assessed the association between a behavioral measure of aberrant salience attribution, the salience attribution test, to neural correlates of RPEs measured via functional magnetic resonance imaging while healthy participants (n = 58) performed an instrumental learning task. A subset of participants (n = 27) also underwent positron emission tomography with the radiotracer [18F]fluoro-l-DOPA to quantify striatal presynaptic dopamine synthesis capacity. Individual variability in aberrant salience measures related negatively to ventral striatal and prefrontal RPE signals and in an exploratory analysis was found to be positively associated with ventral striatal presynaptic dopamine levels. These data provide the first evidence for a specific link between the constructs of aberrant salience attribution, reduced RPE processing, and potentially increased presynaptic dopamine function.

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Language(s): eng - English
 Dates: 2015-02-282015-05-262015-07-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.0805-15.2015
PMID: 26180188
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 35 (28) Sequence Number: - Start / End Page: 10103 - 10111 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187