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  Alterations of gray and white matter networks in patients with obsessive-compulsive disorder: A multimodal fusion analysis of structural MRI and DTI using mCCA+jICA

Kim, S.-G., Jung, W. H., Kim, S. N., Jang, J. H., & Kwon, J. S. (2015). Alterations of gray and white matter networks in patients with obsessive-compulsive disorder: A multimodal fusion analysis of structural MRI and DTI using mCCA+jICA. PLoS One, 10(6): e0127118. doi:10.1371/journal.pone.0127118.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-7E88-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-765C-2
Genre: Journal Article

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Kim, Seung-Goo1, 2, Author              
Jung, Wi Hoon2, Author
Kim, Sung Nyun3, Author
Jang, Joon Hwan3, Author
Kwon, Jun Soo2, 3, 4, Author
Affiliations:
1Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
2Institute of Human Behavioral Medicine, Seoul National University Hospital, Republic of Korea, ou_persistent22              
3Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea, ou_persistent22              
4Department of Brain and Cognitive Sciences, Korea University, Seoul, Republic of Korea, ou_persistent22              

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 Abstract: Many of previous neuroimaging studies on neuronal structures in patients with obsessive-compulsive disorder (OCD) used univariate statistical tests on unimodal imaging measurements. Although the univariate methods revealed important aberrance of local morphometry in OCD patients, the covariance structure of the anatomical alterations remains unclear. Motivated by recent developments of multivariate techniques in the neuroimaging field, we applied a fusion method called “mCCA+jICA” on multimodal structural data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls. Amongst six highly correlated multimodal networks (p lt; 0.0001), we found significant alterations of the interrelated gray and white matter networks over occipital and parietal cortices, frontal interhemispheric connections and cerebella (False Discovery Rate q ≤ 0.05). In addition, we found white matter networks around basal ganglia that correlated with a subdimension of OC symptoms, namely ‘harm/checking’ (q ≤ 0.05). The present study not only agrees with the previous unimodal findings of OCD, but also quantifies the association of the altered networks across imaging modalities.

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Language(s): eng - English
 Dates: 2015-01-052015-04-102015-06-03
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0127118
BibTex Citekey: 10.1371/journal.pone.0127118
PMID: 26038825
PMC: PMC4454537
Other: eCollection 2015
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 10 (6) Sequence Number: e0127118 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850