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  Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

Zaldivar, D., Rauch, A., Whittingstall, K., Logothetis, N., & Goense, J. (2014). Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex. Current Biology, 24(23), 2805-2811. doi:10.1016/j.cub.2014.10.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-7F81-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2212-4
Genre: Journal Article

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Zaldivar, D1, 2, Author              
Rauch, A1, 2, Author              
Whittingstall, K, Author              
Logothetis, NK1, 2, Author              
Goense, J1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Neuromodulators determine how neural circuits process information during cognitive states such as wakefulness, attention, learning, and memory [1]. fMRI can provide insight into their function and dynamics, but their exact effect on BOLD responses remains unclear [2, 3 and 4], limiting our ability to interpret the effects of changes in behavioral state using fMRI. Here, we investigated the effects of dopamine (DA) injections on neural responses and haemodynamic signals in macaque primary visual cortex (V1) using fMRI (7T) and intracortical electrophysiology. Aside from DArsquo;s involvement in diseases such as Parkinsonrsquo;s and schizophrenia, it also plays a role in visual perception [5, 6, 7 and 8]. We mimicked DAergic neuromodulation by systemic injection of L-DOPA and Carbidopa (LDC) or by local application of DA in V1 and found that systemic application of LDC increased the signal-to-noise ratio (SNR) and amplitude of the visually evoked neural responses in V1. However, visually induced BOLD responses decreased, whereas cerebral blood flow (CBF) responses increased. This dissociation of BOLD and CBF suggests that dopamine increases energy metabolism by a disproportionate amount relative to the CBF response, causing the reduced BOLD response. Local application of DA in V1 had no effect on neural activity, suggesting that the dopaminergic effects are mediated by long-range interactions. The combination of BOLD-based and CBF-based fMRI can provide a signature of dopaminergic neuromodulation, indicating that the application of multimodal methods can improve our ability to distinguish sensory processing from neuromodulatory effects.

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 Dates: 2014-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.cub.2014.10.006
BibTex Citekey: ZaldivarRWLG2014
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Title: Current Biology
Source Genre: Journal
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Pages: - Volume / Issue: 24 (23) Sequence Number: - Start / End Page: 2805 - 2811 Identifier: -