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  Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study

Schecklmann, M., Giani, A., Tupak, S., Langguth, B., Raab, V., Polak, T., et al. (2014). Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study. Neural Plasticity, 2014: 894203, pp. 1-8. doi:10.1155/2014/894203.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-7F97-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D0CA-B
Genre: Journal Article

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Schecklmann, M, Author
Giani, A1, 2, Author              
Tupak, S, Author
Langguth, B, Author
Raab, V, Author
Polak, T, Author
Várallyay, C, Author
Harnisch, W, Author
Herrmann, MJ, Author
Fallgatter, AJ, Author
Affiliations:
1Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497797              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Objective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinnitus and from intervention with transcranial magnetic stimulation. Methods. Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. Brain oxygenation was measured once in healthy controls . Results. Sound-evoked activity in right temporal areas was increased in the patients in contrast to healthy controls. Left-sided temporal activity under the stimulated area changed over the course of the trial; high baseline oxygenation was reduced and vice versa. Conclusions. By demonstrating that rTMS interacts with auditory evoked brain activity, our results confirm earlier electrophysiological findings and indicate the sensitivity of fNIRS for detecting rTMS induced changes in brain activity. Moreover, our findings of trait- and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response.

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 Dates: 2014-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1155/2014/894203
BibTex Citekey: SchecklmannGTLRPVHHF2014
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Title: Neural Plasticity
Source Genre: Journal
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Pages: 8 Volume / Issue: 2014 Sequence Number: 894203 Start / End Page: 1 - 8 Identifier: -