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  Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T

Huber, L., Goense, J., Kennerley, A., Ivanov, D., Krieger, S., Lepsien, J., et al. (2014). Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. NeuroImage, 97, 349-362. doi:10.1016/j.neuroimage.2014.04.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-7FED-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2982-E
Genre: Journal Article

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 Creators:
Huber, L, Author
Goense, J1, 2, Author              
Kennerley, AJ, Author
Ivanov, D, Author
Krieger, SN, Author
Lepsien, J, Author
Trampel, R, Author
Turner, R, Author
Möller, HE, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7 T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in lsquo;arterialrsquo; and lsquo;venousrsquo; blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between lsquo;arterialrsquo; and lsquo;venousrsquo; contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms.

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 Dates: 2014-08
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2014.04.022
BibTex Citekey: HuberGKIKLTTM2014
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 97 Sequence Number: - Start / End Page: 349 - 362 Identifier: -