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  Dual-Frequency Calcium-Responsive MRI Agents

Kadjane, P., Platas-Iglesias, C., Boehm-Sturm, P., Truffault, V., Hagberg, G., Hoehn, M., et al. (2014). Dual-Frequency Calcium-Responsive MRI Agents. Chemistry: A European Journal, 20(24), 7351-7362. doi:10.1002/chem.201400159.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-800D-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FE49-1
Genre: Journal Article

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Kadjane, P1, 2, Author              
Platas-Iglesias, C, Author
Boehm-Sturm, P, Author
Truffault, V, Author
Hagberg, G2, 3, Author
Hoehn, M, Author
Logothetis, NK1, 2, Author              
Angelovski, G2, 4, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497796              
4Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              

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 Abstract: Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual-frequency calcium-responsive MRI agents are reported. These are paramagnetic, fluorine-containing complexes that produce remarkably high MRI signal changes at the 1H and 19F frequencies at varying Ca2+ concentrations. The nature of the processes triggered by Ca2+ was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double-frequency tracers hold great promise for development of novel functional MRI methods.

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 Dates: 2014-06
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/chem.201400159
BibTex Citekey: KadjanePBTHHLA2014
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Title: Chemistry: A European Journal
Source Genre: Journal
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Pages: - Volume / Issue: 20 (24) Sequence Number: - Start / End Page: 7351 - 7362 Identifier: -