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  Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects

Papanikolaou, A., Keliris, G., Papageorgiou, T., Shao, Y., Krapp, E., Papageorgiou, E., et al. (2014). Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects. Proceedings of the National Academy of Sciences of the United States of America, 111(16), E1656-E1665. doi:10.1073/pnas.1317074111.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-8039-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-95C1-9
Genre: Journal Article

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Papanikolaou, A1, 2, Author              
Keliris, GA1, 2, Author              
Papageorgiou, TD, Author
Shao, Y1, 2, Author              
Krapp, E, Author
Papageorgiou, E, Author
Stingl, K, Author
Bruckmann, A, Author
Schiefer, U, Author
Logothetis, NK1, 2, Author              
Smirnakis, SM, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Injury to the primary visual cortex (V1) typically leads to loss of conscious vision in the corresponding, homonymous region of the contralateral visual hemifield (scotoma). Several studies suggest that V1 is highly plastic after injury to the visual pathways, whereas others have called this conclusion into question. We used functional magnetic resonance imaging (fMRI) to measure area V1 population receptive field (pRF) properties in five patients with partial or complete quadrantic visual field loss as a result of partial V1+ or optic radiation lesions. Comparisons were made with healthy controls deprived of visual stimulation in one quadrant [ldquo;artificial scotomardquo; (AS)]. We observed no large-scale changes in spared-V1 topography as the V1/V2 border remained stable, and pRF eccentricity versus cortical-distance plots were similar to those of controls. Interestingly, three observations suggest limited reorganization: (i) the distribution of pRF centers in spared-V1 was shifted slightly toward the scotoma border in 2 of 5 patients compared with AS controls; (ii) pRF size in spared-V1 was slightly increased in patients near the scotoma border; and (iii) pRF size in the contralesional hemisphere was slightly increased compared with AS controls. Importantly, pRF measurements yield information about the functional properties of spared-V1 cortex not provided by standard perimetry mapping. In three patients, spared-V1 pRF maps overlapped significantly with dense regions of the perimetric scotoma, suggesting that pRF analysis may help identify visual field locations amenable to rehabilitation. Conversely, in the remaining two patients, spared-V1 pRF maps failed to cover sighted locations in the perimetric map, indicating the existence of V1-bypassing pathways able to mediate useful vision.

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 Dates: 2014-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1073/pnas.1317074111
BibTex Citekey: PapanikolaouKPSKPSBSLS2014
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 111 (16) Sequence Number: - Start / End Page: E1656 - E1665 Identifier: -