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  Navigator based respiratory gating during acquisition and preparation phases for proton liver spectroscopy at 3 T

Hock, A., Valkovic, L., Geier, A., Kuntzen, T., Boesiger, P., & Henning, A. (2014). Navigator based respiratory gating during acquisition and preparation phases for proton liver spectroscopy at 3 T. NMR in Biomedicine, 27(3), 348-355. doi:10.1002/nbm.3069.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-8052-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1F28-1
Genre: Journal Article

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 Creators:
Hock, A, Author
Valkovic, L, Author
Geier, A, Author
Kuntzen, T, Author
Boesiger, P, Author
Henning, A1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528692              

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 Abstract: Proton magnetic resonance spectroscopy (1H MRS) enables the non-invasive investigation of the human liver; however, because of technical difficulties it is not regularly used for diagnosis of liver diseases in clinical routine. Breathing motion is one of the major challenges, as it decreases spectral quality and leads to misplacement of the spectroscopic voxel. To overcome this problem, real-time navigator gating for spectral acquisition and preparation steps (B0 shimming, water frequency determination, receiver gain optimization, and water suppression) combined with short TE, optimized first order projection based B0 shimming, water suppression, and inner-volume saturated point resolved spectroscopy (PRESS) at 3 T is suggested. Simultaneous lipid and trimethylamine quantification is demonstrated by means of phantom, volunteer, and representative patient measurements. Precise localization of the voxel despite respiratory motion, increased spectral quality (higher signal-to-noise ratio and reduced linewidth) compared with measurements without respiratory gating, and the possibility of acquiring data without additional subject instructions regarding breathing enable robust and accurate liver 1H MRS measurements with this novel acquisition protocol.

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 Dates: 2014-012014-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/nbm.3069
BibTex Citekey: HockVBH2013
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 27 (3) Sequence Number: - Start / End Page: 348 - 355 Identifier: -