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  Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children

Skeide, M. A., Kirsten, H., Kraft, I., Schaadt, G., Müller, B., Neef, N., et al. (2015). Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children. NeuroImage, 118, 414-421. doi:10.1016/j.neuroimage.2015.06.024.

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Skeide, Michael A.1, Autor           
Kirsten, Holger2, 3, 4, Autor
Kraft, Indra1, Autor           
Schaadt, Gesa1, 5, Autor           
Müller, Bent2, Autor
Neef, Nicole1, Autor           
Brauer, Jens1, Autor           
Wilcke, Arndt2, Autor
Emmrich, Frank2, 6, Autor
Boltze, Johannes2, 6, 7, Autor
Friederici, Angela D.1, Autor           
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department of Cognitive Genetics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
3Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
6Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Germany, ou_persistent22              
7Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              

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 Zusammenfassung: Phonological awareness is the best-validated predictor of reading and spelling skill and therefore highly relevant for developmental dyslexia. Prior imaging genetics studies link several dyslexia risk genes to either brain-functional or brain-structural factors of phonological deficits. However, coherent evidence for genetic associations with both functional and structural neural phenotypes underlying variation in phonological awareness has not yet been provided. Here we demonstrate that rs11100040, a reported modifier of SLC2A3, is related to the functional connectivity of left fronto-temporal phonological processing areas at resting state in a sample of 9- to 12-year-old children. Furthermore, we provide evidence that rs11100040 is related to the fractional anisotropy of the arcuate fasciculus, which forms the structural connection between these areas. This structural connectivity phenotype is associated with phonological awareness, which is in turn associated with the individual retrospective risk scores in an early dyslexia screening as well as to spelling. These results suggest a link between a dyslexia risk genotype and a functional as well as a structural neural phenotype, which is associated with a phonological awareness phenotype. The present study goes beyond previous work by integrating genetic, brain-functional and brain-structural aspects of phonological awareness within a single approach. These combined findings might be another step towards a multimodal biomarker for developmental dyslexia.

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Sprache(n): eng - English
 Datum: 2014-12-102015-06-062015-06-122015-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2015.06.024
PMID: 26080313
Anderer: Epub 2015
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 118 Artikelnummer: - Start- / Endseite: 414 - 421 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166