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  Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children

Skeide, M. A., Kirsten, H., Kraft, I., Schaadt, G., Müller, B., Neef, N., et al. (2015). Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children. NeuroImage, 118, 414-421. doi:10.1016/j.neuroimage.2015.06.024.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-8128-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-152C-5
Genre: Journal Article

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 Creators:
Skeide, Michael A.1, Author              
Kirsten, Holger2, 3, 4, Author
Kraft, Indra1, Author              
Schaadt, Gesa1, 5, Author              
Müller, Bent2, Author
Neef, Nicole1, Author              
Brauer, Jens1, Author              
Wilcke, Arndt2, Author
Emmrich, Frank2, 6, Author
Boltze, Johannes2, 6, 7, Author
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department of Cognitive Genetics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
3Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
6Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Germany, ou_persistent22              
7Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              

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 Abstract: Phonological awareness is the best-validated predictor of reading and spelling skill and therefore highly relevant for developmental dyslexia. Prior imaging genetics studies link several dyslexia risk genes to either brain-functional or brain-structural factors of phonological deficits. However, coherent evidence for genetic associations with both functional and structural neural phenotypes underlying variation in phonological awareness has not yet been provided. Here we demonstrate that rs11100040, a reported modifier of SLC2A3, is related to the functional connectivity of left fronto-temporal phonological processing areas at resting state in a sample of 9- to 12-year-old children. Furthermore, we provide evidence that rs11100040 is related to the fractional anisotropy of the arcuate fasciculus, which forms the structural connection between these areas. This structural connectivity phenotype is associated with phonological awareness, which is in turn associated with the individual retrospective risk scores in an early dyslexia screening as well as to spelling. These results suggest a link between a dyslexia risk genotype and a functional as well as a structural neural phenotype, which is associated with a phonological awareness phenotype. The present study goes beyond previous work by integrating genetic, brain-functional and brain-structural aspects of phonological awareness within a single approach. These combined findings might be another step towards a multimodal biomarker for developmental dyslexia.

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Language(s): eng - English
 Dates: 2014-12-102015-06-062015-06-122015-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.06.024
PMID: 26080313
Other: Epub 2015
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 118 Sequence Number: - Start / End Page: 414 - 421 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166