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  Functional network centrality in obesity: A resting-state and task fMRI study

Garcia-Garcia, I., Jurado, M. A., Garolera, M., Marques-Iturria, I., Horstmann, A., Segura, B., et al. (2015). Functional network centrality in obesity: A resting-state and task fMRI study. Psychiatry Research: Neuroimaging, 233(3), 331-338. doi:10.1016/j.pscychresns.2015.05.017.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-81AF-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-78FB-C
Genre: Journal Article

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 Creators:
Garcia-Garcia, Isabel1, 2, Author              
Jurado, M. A.1, 3, 4, Author
Garolera, Maite4, 5, Author
Marques-Iturria, I.1, 3, Author
Horstmann, Annette2, 6, Author              
Segura, B.1, 4, Author
Pueyo, R.1, 3, 4, Author
Sender-Palacios, M. J.7, Author
Vernet-Vernet, M.7, Author
Villringer, Arno2, Author              
Junqué, Carmen1, 4, 8, Author
Margulies, Daniel S.9, Author              
Neumann, Jane2, 6, Author              
Affiliations:
1Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Institute for Brain, Cognition and Behaviour, Barcelona, Spain, ou_persistent22              
4Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain, ou_persistent22              
5Neuropsychology Unit, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              
6Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
7CAP Terrassa Nord, Consorci Sanitari de Terrassa, Barcelona, Spain, ou_persistent22              
8Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ou_persistent22              
9Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_1356546              

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Free keywords: AFNI; Analysis of functional neuroimages; BMI; Body-mass index; FSL, FMRIB software library; fMRI; Functional magnetic resonance imaging; ICA; Independent component analysis; SCID-I; Structured clinical interview for DSM-IV; SPM; Statistical parametric mapping
 Abstract: Obesity is associated with structural and functional alterations in brain areas that are often functionally distinct and anatomically distant. This suggests that obesity is associated with differences in functional connectivity of regions distributed across the brain. However, studies addressing whole brain functional connectivity in obesity remain scarce. Here, we compared voxel-wise degree centrality and eigenvector centrality between participants with obesity (n=20) and normal-weight controls (n=21). We analyzed resting state and task-related fMRI data acquired from the same individuals. Relative to normal-weight controls, participants with obesity exhibited reduced degree centrality in the right middle frontal gyrus in the resting-state condition. During the task fMRI condition, obese participants exhibited less degree centrality in the left middle frontal gyrus and the lateral occipital cortex along with reduced eigenvector centrality in the lateral occipital cortex and occipital pole. Our results highlight the central role of the middle frontal gyrus in the pathophysiology of obesity, a structure involved in several brain circuits signaling attention, executive functions and motor functions. Additionally, our analysis suggests the existence of task-dependent reduced centrality in occipital areas; regions with a role in perceptual processes and that are profoundly modulated by attention.

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Language(s): eng - English
 Dates: 2014-08-012015-05-282015-06-192015-09-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 26145769
DOI: 10.1016/j.pscychresns.2015.05.017
Other: Epub 2015
 Degree: -

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Title: Psychiatry Research: Neuroimaging
  Other : Psychiatry Res. Neuroimaging
Source Genre: Journal
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Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 233 (3) Sequence Number: - Start / End Page: 331 - 338 Identifier: ISSN: 0925-4927
CoNE: /journals/resource/954925566740