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  Long lasting activity of nociceptive muscular afferents facilitates bilateral flexion reflex pattern in the feline spinal cord.

Schomburg, E. D., Steffens, H., Pilyavskii, A. I., Maisky, V. A., Brück, W., Dibaj, P., et al. (2015). Long lasting activity of nociceptive muscular afferents facilitates bilateral flexion reflex pattern in the feline spinal cord. Neuroscience Research, 95, 51-58. doi:10.1016/j.neures.2015.01.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-829D-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CE29-7
Genre: Journal Article

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2161138.pdf (Publisher version), 655KB
 
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Schomburg, E. D., Author
Steffens, H.1, Author              
Pilyavskii, A. I., Author
Maisky, V. A., Author
Brück, W., Author
Dibaj, P., Author
Sears, T. A., Author
Affiliations:
1Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society, ou_578627              

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Free keywords: Muscle inflammation; Carrageenan; Freund's adjuvant; Bilateral spinal reflex transmission; Sensorimotor control
 Abstract: Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investigated bilaterally their reflex responses conditioned by (a) acute 'myositis' induced by intramuscular carrageenan; and (b) sub-acute 'myositis' induced by infusion of complete Freund's adjuvant (CFA). Reflex transmission was detected by monosynaptic testing and c-fos staining used to identify increased neuronal activity. In all control experiments with chemical stimulation of group III/IV afferents, ipsilateral responses conformed to the flexor reflex pattern. However, the expected contralateral facilitation of GS motoneurones occurred in fewer than 50% trials while only 9% of trials induced contralateral inhibition of flexor posterior-biceps-semitendinosus (PBSt) motoneurones. During carrageenan acute myositis contralateral PBSt was transiently facilitated by selective activation of group III/IV afferents. During CFA-induced myositis, contralateral only inhibition of GS motoneurones occurred instead of any facilitation, while bidirectionally a crossed facilitation of PBST dominated. These reflex changes were mirrored in an enhanced number of neurones with enhanced c-fos expression. Muscle pain, particularly if chronically persistent, requires another behavioural response pattern than acute exteroceptive pain

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Language(s): eng - English
 Dates: 2015-01-202015-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neures.2015.01.003
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Title: Neuroscience Research
Source Genre: Journal
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Pages: - Volume / Issue: 95 Sequence Number: - Start / End Page: 51 - 58 Identifier: -