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  A Tutorial on Mathematical Modeling of Biological Signaling Pathways

Zi, Z. (2012). A Tutorial on Mathematical Modeling of Biological Signaling Pathways. In X. Liu, & M. D. Betterton (Eds.), Computational Modeling of Signaling Networks (pp. 41-51). Humana Press.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-9E53-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-9E54-3
Genre: Book Chapter

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© 2012 Springer International Publishing AG, Part of Springer Science+Business Media
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 Creators:
Zi, Zhike1, Author              
Affiliations:
1Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117284              

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 Abstract: Mathematical models have been widely used in the studies of biological signaling pathways. Among these studies, two systems biology approaches have been applied: top-down and bottom-up systems biology. The former approach focuses on X-omics researches involving the measurement of experimental data in a large scale, for example proteomics, metabolomics, or fluxomics and transcriptomics. In contrast, the bottom-up approach studies the interaction of the network components and employs mathematical models to gain some insights about the mechanisms and dynamics of biological systems. This chapter introduces how to use the bottom-up approach to establish mathematical models for cell signaling studies.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/978-1-61779-833-7_3
 Degree: -

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Source 1

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Title: Computational Modeling of Signaling Networks
Source Genre: Book
 Creator(s):
Liu, Xuedong, Editor
Betterton, Meredith D., Editor
Affiliations:
-
Publ. Info: Humana Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 41 - 51 Identifier: ISBN: 978-1-61779-832-0

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Title: Methods in molecular biology
Source Genre: Series
 Creator(s):
Walker, John M., Editor
Affiliations:
-
Publ. Info: Humana Press
Pages: 327 Volume / Issue: 880 Sequence Number: - Start / End Page: - Identifier: ISSN: 1064-3745