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  Dynamics of TGF-β/Smad signaling

Zi, Z., Chapnick, D. A., & Liu, X. (2012). Dynamics of TGF-β/Smad signaling. FEBS Letters, 586(14), 1921-1928. doi:10.1016/j.febslet.2012.03.063.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A10A-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A10B-1
Genre: Journal Article

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© 2012 Federation of European Biochemical Societies
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 Creators:
Zi, Zhike1, Author              
Chapnick, Douglas A., Author
Liu, Xuedong, Author
Affiliations:
1Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117284              

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Free keywords: TGF-β, Smad, mathematical model, dose response, switch-like response
 Abstract: The physiological responses to TGF-β stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the noncanonical TGF-β signaling pathways have been largely identified, the mechanism that underlies the well-established context dependent physiological responses remains a mystery. Understanding how the components of TGF-β signaling function as a system and how this system functions in the context of the global cellular regulatory network requires a more quantitative and systematic approach. Here, we review the recent progress in understanding TGF-β biology using integration of mathematical modeling and quantitative experimental analysis. These studies reveal many interesting dynamics of TGF-β signaling and how cells quantitatively decode variable doses of TGF-β stimulation.

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Language(s): eng - English
 Dates: 2012-04-092012-07-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.febslet.2012.03.063
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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 586 (14) Sequence Number: - Start / End Page: 1921 - 1928 Identifier: ISSN: 0014-5793
CoNE: /journals/resource/954925399501