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  In silico identification of the key components and steps in IFN-γ induced JAK-STAT signaling pathway

Zi, Z., Cho, K.-H., Sung, M.-H., Xia, X., Zheng, J., & Sun, Z. (2005). In silico identification of the key components and steps in IFN-γ induced JAK-STAT signaling pathway. FEBS Letters, 579(5), 1101-1108. doi:10.1016/j.febslet.2005.01.009.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A218-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A219-4
Genre: Journal Article

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© 2005 Federation of European Biochemical Societies
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 Creators:
Zi, Zhike1, Author              
Cho, Kwang-Hyun, Author
Sung, Myong-Hee, Author
Xia, Xuefeng, Author
Zheng, Jiashun, Author
Sun, Zhirong, Author
Affiliations:
1Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117284              

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Free keywords: Janus kinase-signal transducers and activators of transcription; Interferon gamma; Robustness analysis; Multi-parametric sensitivity analysis; Systems biology
 Abstract: Systems biology efforts are increasingly adopting quantitative, mechanistic modeling to study cellular signal transduction pathways and other networks. However, it is uncertain whether the particular set of kinetic parameter values of the model closely approximates the corresponding biological system. We propose that the parameters be assigned statistical distributions that reflect the degree of uncertainty for a comprehensive simulation analysis. From this analysis, we globally identify the key components and steps in signal transduction networks at a systems level. We investigated a recent mathematical model of interferon gamma induced Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway by applying multi-parametric sensitivity analysis that is based on simultaneous variation of the parameter values. We find that suppressor of cytokine signaling-1, nuclear phosphatases, cytoplasmic STAT1, and the corresponding reaction steps are sensitive perturbation points of this pathway.

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Language(s): eng - English
 Dates: 2005-02-14
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.febslet.2005.01.009
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 579 (5) Sequence Number: - Start / End Page: 1101 - 1108 Identifier: ISSN: 0014-5793
CoNE: /journals/resource/954925399501