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  Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12

Schulz, E. G., Mariani, L., Radbruch, A., & Höfer, T. (2009). Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity, 30(5), 673-683. doi:10.1016/j.immuni.2009.03.013.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A272-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A273-9
Genre: Journal Article

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 Creators:
Schulz, Edda G.1, Author              
Mariani, Luca, Author
Radbruch, Andreas, Author
Höfer, Thomas, Author
Affiliations:
1Regulatory Networks in Stem Cells (Edda G. Schulz), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117286              

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Free keywords: MOLIMMUNO
 Abstract: Differentiation of naive T lymphocytes into type I T helper (Th1) cells requires interferon-γ and interleukin-12. It is puzzling that interferon-γ induces the Th1 transcription factor T-bet, whereas interleukin-12 mediates Th1 cell lineage differentiation. We use mathematical modeling to analyze the expression kinetics of T-bet, interferon-γ, and the IL-12 receptor β2 chain (IL-12Rβ2) during Th1 cell differentiation, in the presence or absence of interleukin-12 or interferon-γ signaling. We show that interferon-γ induced initial T-bet expression, whereas IL-12Rβ2 was repressed by T cell receptor (TCR) signaling. The termination of TCR signaling permitted upregulation of IL-12Rβ2 by T-bet and interleukin-12 signaling that maintained T-bet expression. This late expression of T-bet, accompanied by the upregulation of the transcription factors Runx3 and Hlx, was required to imprint the Th cell for interferon-γ re-expression. Thus initial polarization and subsequent imprinting of Th1 cells are mediated by interlinked, sequentially acting positive feedback loops of TCR-interferon-γ-Stat1-T-bet and interleukin-12-Stat4-T-bet signaling.

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Language(s): eng - English
 Dates: 2009-04-302009-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.immuni.2009.03.013
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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 30 (5) Sequence Number: - Start / End Page: 673 - 683 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783