English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Zeigerer, A., Bogorad, R. L., Sharma, K., Gilleron, J., Seifert, S., Sales, S., et al. (2015). Regulation of Liver Metabolism by the Endosomal GTPase Rab5. CELL REPORTS, 11(6), 884-892. doi:10.1016/j.celrep.2015.04.018.

Item is

Files

show Files
hide Files
:
1-s2.0-S2211124715004052-main.pdf (Any fulltext), 4MB
Name:
1-s2.0-S2211124715004052-main.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
open access article
License:
-

Locators

show

Creators

show
hide
 Creators:
Zeigerer, Anja1, Author
Bogorad, Roman L.1, Author
Sharma, Kirti2, Author           
Gilleron, Jerome1, Author
Seifert, Sarah1, Author
Sales, Susanne1, Author
Berndt, Nikolaus1, Author
Bulik, Sascha1, Author
Marsico, Giovanni1, Author
D'Souza, Rochelle C. J.2, Author           
Lakshmanaperumal, Naharajan1, Author
Meganathan, Kesavan1, Author
Natarajan, Karthick1, Author
Sachinidis, Agapios1, Author
Dahl, Andreas1, Author
Holzhuetter, Hermann-Georg1, Author
Shevchenko, Andrej1, Author
Mann, Matthias2, Author           
Koteliansky, Victor1, Author
Zerial, Marino1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Content

show
hide
Free keywords: HEPATIC GLUCOSE-PRODUCTION; SHOTGUN LIPIDOMICS; DISEASE; ENDOCYTOSIS; QUANTIFICATION; COACTIVATORS; TRAFFICKING; DEFICIENCY; AUTOPHAGY; EFFECTORS
 Abstract: The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed the question of whether endosomes are required for gluconeogenic gene expression. We took advantage of the loss of endosomes in the mouse liver upon Rab5 silencing. Strikingly, we found hepatomegaly and severe metabolic defects such as hypoglycemia, hypercholesterolemia, hyperlipidemia, and glycogen accumulation that phenocopied those found in von Gierke's disease, a glucose-6-phosphatase (G6Pase) deficiency. G6Pase deficiency alone can account for the reduction in hepatic glucose output and glycogen accumulation as determined by mathematical modeling. Interestingly, we uncovered functional alterations in the transcription factors, which regulate G6Pase expression. Our data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.

Details

show
hide
Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: CELL REPORTS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 11 (6) Sequence Number: - Start / End Page: 884 - 892 Identifier: ISSN: 2211-1247