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  The CatSper channel controls chemosensation in sea urchin sperm

Seifert, R., Flick, M., Bönigk, W., Alvarez, L., Trötschel, C., Poetsch, A., et al. (2015). The CatSper channel controls chemosensation in sea urchin sperm. EMBO Journal, 34(3), 379-392. doi:10.15252/embj.201489376.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A647-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-FDE4-2
Genre: Journal Article

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 Creators:
Seifert, Reinhard, Author
Flick, Melanie, Author
Bönigk, Wolfgang, Author
Alvarez, Luis, Author
Trötschel, Christian, Author
Poetsch, Ansgar, Author
Müller, Astrid, Author
Goodwin, Normann, Author
Pelzer, Patric, Author
Kashikar, Nachiket D., Author
Kremmer, Elisabeth, Author
Jikeli, Jan, Author
Timmermann, Bernd1, Author              
Kuhl, Heiner1, Author              
Fridman, Dmitry, Author
Windler, Florian, Author
Kaupp, U. Benjamin, Author
Strünker, Timo, Author
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts. The underlying Ca2+ channel and its mechanisms of activation are unknown. Here, we identify CatSper Ca2+ channels in the flagellum of A. punctulata sperm. We show that CatSper mediates the chemoattractant‐evoked Ca2+ influx and controls chemotactic steering; a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca2+ bursts. Our results reveal intriguing phylogenetic commonalities but also variations between marine invertebrates and mammals regarding the function and control of CatSper. The variations probably reflect functional and mechanistic adaptations that evolved during the transition from external to internal fertilization.

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Language(s): eng - English
 Dates: 2014-12-222015-02-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.15252/embj.201489376
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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 34 (3) Sequence Number: - Start / End Page: 379 - 392 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061