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  Oxyntomodulin regulates resetting of the liver circadian clock by food.

Landgraf, D., Tsang, A. H., Leliavski, A., Koch, C. E., Barclay, J. L., Drucker, D. J., et al. (2015). Oxyntomodulin regulates resetting of the liver circadian clock by food. eLife, 4: e06253. doi:10.7554/eLife.06253.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A8A4-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1A1A-1
Genre: Journal Article

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 Creators:
Landgraf, D.1, Author              
Tsang, A. H.1, Author              
Leliavski, A.2, Author              
Koch, C. E., Author
Barclay, J. L.2, Author              
Drucker, D. J., Author
Oster, H.2, Author              
Affiliations:
1Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society, ou_persistent34              
2Research Group of Circadian Rhythms, MPI for biophysical chemistry, Max Planck Society, ou_578594              

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Free keywords: Per; biochemistry; cell biology; circadian clock; clock genes; food resetting; liver; mouse
 Abstract: Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light-dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. Alterations in food intake rhythms can uncouple peripheral clocks from the SCN, resulting in internal desynchrony, which promotes obesity and metabolic disorders. Pancreas-derived hormones such as insulin and glucagon have been implicated in signaling mealtime to peripheral clocks. In this study, we identify a novel, more direct pathway of food-driven liver clock resetting involving oxyntomodulin (OXM). In mice, food intake stimulates OXM secretion from the gut, which resets liver transcription rhythms via induction of the core clock genes Per1 and 2. Inhibition of OXM signaling blocks food-mediated resetting of hepatocyte clocks. These data reveal a direct link between gastric filling with food and circadian rhythm phasing in metabolic tissues.

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Language(s): eng - English
 Dates: 2015-03-30
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.06253
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Title: eLife
Source Genre: Journal
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Pages: 16 Volume / Issue: 4 Sequence Number: e06253 Start / End Page: - Identifier: -