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  Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata)

Kottler, V. A., Künstner, A., Koch, I., Flötenmeyer, M., Langenecker, T., Hoffmann, M., et al. (2015). Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata). Pigment Cell & Melanoma Research, 28(5): 12386, pp. 545-558. doi:10.1111/pcmr.12386.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A911-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-4637-6
Genre: Journal Article

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Kottler_et_al_2015_2.pdf (Publisher version), 2MB
 
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 Creators:
Kottler, Verena A., Author
Künstner, Axel1, Author              
Koch, Iris, Author
Flötenmeyer, Matthias, Author
Langenecker, Tobias, Author
Hoffmann, Margarete, Author
Sharma, Eshita, Author
Weigel, Detlef, Author
Dreyer, Christine, Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: Guppy; pigmentation; ddRADseq; QTL mapping; Adenylate cyclase; adcy5
 Abstract: Guppies (Poecilia reticulata) are colorful fish that have attracted the attention of pigmentation researchers for almost a century. Here, we report that the blond phenotype of the guppy is caused by a spontaneous mutation in the guppy ortholog of adenylate cyclase 5 (adcy5). Using double digest restriction site-associated DNA sequencing (ddRADseq) and quantitative trait locus (QTL) mapping, we linked the blond phenotype to a candidate region of 118 kb, in which we subsequently identified a 2-bp deletion in adcy5 that alters splicing and leads to a premature stop codon. We show that adcy5, which affects lifespan and melanoma growth in mouse, is required for melanophore development and formation of male orange pigmentation traits in the guppy. We find that some components of the male orange pattern are particularly sensitive to loss of Adcy5 function. Our work thus reveals a function for Adcy5 in patterning of fish color ornaments.

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Language(s): eng - English
 Dates: 2015-05-052015-06-092015-05-272015-06-162015-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/pcmr.12386
 Degree: -

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Title: Pigment Cell & Melanoma Research
  Other : (Formerly: Pigment Cell Research)
  Abbreviation : Pigment Cell Melanoma Res.
Source Genre: Journal
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Publ. Info: Oxford : Wiley-Blackwell
Pages: - Volume / Issue: 28 (5) Sequence Number: 12386 Start / End Page: 545 - 558 Identifier: ISSN: 0893-5785 (print)
ISSN: 1755-1471 (print)
ISSN: 1600-0749 (online)
n.a.: 1755-148X (online)
CoNE: /journals/resource/pigmentcellres