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  Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson's disease

Bunzeck, N., Singh-Curry, V., Eckart, C., Weiskopf, N., Perry, R. J., Bain, P. G., et al. (2013). Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson's disease. Parkinsonism & Related Disorders, 19(12), 1136-1142. doi:10.1016/j.parkreldis.2013.08.011.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-AAEB-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-843B-6
Genre: Journal Article

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 Creators:
Bunzeck, Nico1, Author
Singh-Curry, Victoria2, 3, Author
Eckart, Cindy1, Author
Weiskopf, Nikolaus4, Author              
Perry, Richard J.5, Author
Bain, Peter G.5, Author
Düzel, Emrah2, 6, 7, Author
Husain, Masud2, 3, 8, 9, Author
Affiliations:
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
2Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
3Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
5Imperial College London, United Kingdom, ou_persistent22              
6Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
7German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
8Nuffield Department Clinical Neurosciences, University of Oxford, United Kingdom, ou_persistent22              
9Department of Experimental Psychology, University of Oxford, United Kingdom, ou_persistent22              

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Free keywords: Basal ganglia; Iron; Magnetic resonance imaging; Motor subtypes; Parkinson's disease
 Abstract: BACKGROUND: In Parkinson's disease the degree of motor impairment can be classified with respect to tremor dominant and akinetic rigid features. While tremor dominance and akinetic rigidity might represent two ends of a continuum rather than discrete entities, it would be important to have non-invasive markers of any biological differences between them in vivo, to assess disease trajectories and response to treatment, as well as providing insights into the underlying mechanisms contributing to heterogeneity within the Parkinson's disease population. METHODS: Here, we used magnetic resonance imaging to examine whether Parkinson's disease patients exhibit structural changes within the basal ganglia that might relate to motor phenotype. Specifically, we examined volumes of basal ganglia regions, as well as transverse relaxation rate (a putative marker of iron load) and magnetization transfer saturation (considered to index structural integrity) within these regions in 40 individuals. RESULTS: We found decreased volume and reduced magnetization transfer within the substantia nigra in Parkinson's disease patients compared to healthy controls. Importantly, there was a positive correlation between tremulous motor phenotype and transverse relaxation rate (reflecting iron load) within the putamen, caudate and thalamus. CONCLUSIONS: Our findings suggest that akinetic rigid and tremor dominant symptoms of Parkinson's disease might be differentiated on the basis of the transverse relaxation rate within specific basal ganglia structures. Moreover, they suggest that iron load within the basal ganglia makes an important contribution to motor phenotype, a key prognostic indicator of disease progression in Parkinson's disease.

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Language(s): eng - English
 Dates: 2013-07-042013-05-142013-08-192013-08-292013-12-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.parkreldis.2013.08.011
PMID: 24025315
PMC: PMC3878384
Other: Epub 2013
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Title: Parkinsonism & Related Disorders
Source Genre: Journal
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Pages: - Volume / Issue: 19 (12) Sequence Number: - Start / End Page: 1136 - 1142 Identifier: ISSN: 1353-8020
CoNE: https://pure.mpg.de/cone/journals/resource/954925618102