English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The fusion pore.

Lindau, M., & de Toledo, A. (2003). The fusion pore. Biochimica et Biophysica Acta-Molecular Cell Research, 1641(2-3), 167-173. doi:10.1016/S0167-4889(03)00085-5.

Item is

Files

show Files
hide Files
:
2167166.pdf (Publisher version), 201KB
Name:
2167166.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Lindau, M.1, Author              
de Toledo, A., Author
Affiliations:
1Research Group of Nanoscale Cell Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1832294              

Content

show
hide
Free keywords: membrane fusion; fusion pore; exocytosis; kiss-and-run; transmitter release
 Abstract: The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion pore is formed and the contents are released. Release of neurotransmitter is an extremely rapid event leading to rise times of the postsynaptic response of less than 100 mus. The release thus occurs during the initial formation of the exocytotic fusion pore. To understand the process of synaptic transmission, it is thus of outstanding importance to understand the molecular structure of the fusion pore, what are the properties of the initial fusion pore, how these properties affect the release process and what other factors may be limiting the kinetics of release. Here we review the techniques currently employed in fusion pore studies and discuss recent data and opinions on exocytotic fusion pore properties.

Details

show
hide
Language(s): eng - English
 Dates: 2003-08-18
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0167-4889(03)00085-5
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biochimica et Biophysica Acta-Molecular Cell Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 1641 (2-3) Sequence Number: - Start / End Page: 167 - 173 Identifier: -