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  Diagnosis of gastroesophageal reflux disease using real-time magnetic resonance imaging.

Zhang, S., Joseph, A. A., Gross, L., Ghadimi, M., Frahm, J., & Beham, A. (2015). Diagnosis of gastroesophageal reflux disease using real-time magnetic resonance imaging. Scientific Reports, 5: 12112. doi:10.1038/srep12112.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-AAF7-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-21F2-6
Genre: Journal Article

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Zhang, S.1, Author              
Joseph, A. A.1, Author              
Gross, L., Author
Ghadimi, M., Author
Frahm, J.1, Author              
Beham, A., Author
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1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: A small angle (His angle) between the oesophagus and the fundus of the stomach is considered to act as flap valve and anti-reflux barrier. A wide angle results in dysfunction of the oesophagogastric junction and subsequently in gastroesophageal reflux disease (GERD). Here, we used real-time magnetic resonance imaging (MRI) at 50 ms resolution (20 frames per second) in 12 volunteers and 12 patients with GERD to assess transport of pineapple juice through the oesophagogastric junction and reflux during Valsalva. We found that the intra-abdominal part of the oesophagus was bended towards the left side resulting in an angle of 75.3 ± 17.4, which was significantly larger during Valsava (P = 0.017). Reflux and several underlying pathologies were detected in 11 out of 12 patients. Our data visualize oesophagogastric junction physiology and disprove the flap valve hypothesis. Further, non-invasive real-time MRI has considerable potential for the diagnosis of causative pathologies leading to GERD.

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Language(s): eng - English
 Dates: 2015-07-15
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/srep12112
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Title: Scientific Reports
Source Genre: Journal
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Pages: 10 Volume / Issue: 5 Sequence Number: 12112 Start / End Page: - Identifier: -