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  Quantitative multi-parameter mapping of R1, PD(*), MT, and R2(*) at 3T: A multi-center validation

Weiskopf, N., Suckling, J., Williams, G., Correia, M. M., Inkster, B., Tait, R., et al. (2013). Quantitative multi-parameter mapping of R1, PD(*), MT, and R2(*) at 3T: A multi-center validation. Frontiers in Neuroscience, 7: 95. doi:10.3389/fnins.2013.00095.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-AE65-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-846A-1
Genre: Journal Article

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 Creators:
Weiskopf, Nikolaus1, Author              
Suckling, John2, 3, 4, Author
Williams, Guy3, 5, Author
Correia, Marta M.6, Author
Inkster, Becky2, Author
Tait, Roger3, Author
Ooi, Cinly2, 3, Author
Bullmore, Edward T.2, 3, 4, 7, Author
Lutti, Antoine1, 8, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
3Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom, ou_persistent22              
4Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom, ou_persistent22              
5Department of Clinical Neuroscience, Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom, ou_persistent22              
6MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              
7GlaxoSmithKline, Clinical Unit Cambridge, Addenbrooke's Hospital, United Kingdom, ou_persistent22              
8Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              

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Free keywords: 3T; MPM; MT; PD; T1; T2*; multi-center; qMRI
 Abstract: Multi-center studies using magnetic resonance imaging facilitate studying small effect sizes, global population variance and rare diseases. The reliability and sensitivity of these multi-center studies crucially depend on the comparability of the data generated at different sites and time points. The level of inter-site comparability is still controversial for conventional anatomical T1-weighted MRI data. Quantitative multi-parameter mapping (MPM) was designed to provide MR parameter measures that are comparable across sites and time points, i.e., 1 mm high-resolution maps of the longitudinal relaxation rate (R1 = 1/T1), effective proton density (PD(*)), magnetization transfer saturation (MT) and effective transverse relaxation rate (R2(*) = 1/T2(*)). MPM was validated at 3T for use in multi-center studies by scanning five volunteers at three different sites. We determined the inter-site bias, inter-site and intra-site coefficient of variation (CoV) for typical morphometric measures [i.e., gray matter (GM) probability maps used in voxel-based morphometry] and the four quantitative parameters. The inter-site bias and CoV were smaller than 3.1 and 8%, respectively, except for the inter-site CoV of R2(*) (<20%). The GM probability maps based on the MT parameter maps had a 14% higher inter-site reproducibility than maps based on conventional T1-weighted images. The low inter-site bias and variance in the parameters and derived GM probability maps confirm the high comparability of the quantitative maps across sites and time points. The reliability, short acquisition time, high resolution and the detailed insights into the brain microstructure provided by MPM makes it an efficient tool for multi-center imaging studies.

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Language(s): eng - English
 Dates: 2013-02-042013-05-182013-06-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnins.2013.00095
PMID: 23772204
PMC: PMC3677134
Other: eCollection 2013
 Degree: -

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 7 Sequence Number: 95 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548