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  Multi-center mapping of structural network alterations in autism

Valk, S. L., DiMartino, A., Milham, M., & Bernhardt, B. C. (2015). Multi-center mapping of structural network alterations in autism. Human Brain Mapping, 36(6), 2364-2373. doi:10.1002/hbm.22776.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-AD9E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7941-C
Genre: Journal Article

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 Creators:
Valk, Sofie L.1, Author              
DiMartino, Adriana2, Author
Milham, M.ichael3, 4, Author
Bernhardt, Boris C.1, 5, Author              
Affiliations:
1Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
2Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, New York University Child Study Center, NY, USA, ou_persistent22              
3Child Mind Institute, New York, NY, USA, ou_persistent22              
4Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
5McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

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Free keywords: ASD; ABIDE; Neocortex; Connectivity; Medial PFC; Connectome
 Abstract: Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions primarily characterized by abnormalities in social cognition. Abundant previous functional MRI studies have shown atypical activity in networks encompassing medial prefrontal cortex (mPFC) and medial parietal regions corresponding to posterior cingulate cortex and precuneus (PCC/PCU). Conversely, studies assessing structural brain anomalies in ASD have been rather inconsistent. The current work evaluated whether structural changes in ASD can be reliability detected in a large multicenter dataset. Our comprehensive structural MRI framework encompassed cortical thickness mapping and structural covariance analysis based on three independent samples comprising individuals with ASD and controls (n = 220), selected from the Autism Brain Imaging Data Exchange open-access database. Surface-based analysis revealed increased cortical thickness in ASD relative to controls in mPFC and lateral prefrontal cortex. Clusters encompassing mPFC were embedded in altered inter-regional covariance networks, showing decreased covariance in ASD relative to controls primarily to PCC/PCU and inferior parietal regions. Cortical thickness increases and covariance reductions in ASD were consistent, yet of variable effect size, across the different sites evaluated and measurable both in children and adults. Our multisite study shows regional and network-level structural alterations in mPFC in ASD that, possibly, relate to atypical socio-cognitive functions in this condition.

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Language(s): eng - English
 Dates: 2014-09-042015-02-132015-02-252015-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22776
PMID: 25727858
PMC: PMC6129398
Other: Epub 2015
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 36 (6) Sequence Number: - Start / End Page: 2364 - 2373 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686