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  The influence of oxytocin on volitional and emotional ambivalence

Preckel, K., Scheele, D., Eckstein, M., Maier, W., & Hurlemann, R. (2015). The influence of oxytocin on volitional and emotional ambivalence. Social Cognitive and Affective Neuroscience, 10(7), 987-983. doi:10.1093/scan/nsu147.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-ADBB-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7925-C
Genre: Journal Article

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 Creators:
Preckel, Katrin1, 2, Author              
Scheele, Dirk1, 2, Author
Eckstein, Monika1, 2, Author
Maier, Wolfgang1, 3, Author
Hurlemann, René1, 2, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Bonn, Germany, ou_persistent22              
2Department of Psychology, University Bonn, Germany, ou_persistent22              
3German Center for Neurodegenerative Diseases, Bonn, Germany, ou_persistent22              

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Free keywords: Ambivalence; Anterior cingulate cortex; fMRI; Jealousy; Moral; Oxytocin
 Abstract: Moral decisions and social relationships are often characterized by strong feelings of ambivalence which can be a catalyst for emotional distress and several health-related problems. The anterior cingulate cortex (ACC) has been identified as a key brain region in monitoring conflicting information, but the neurobiological substrates of ambivalence processing are still widely unknown. We have conducted two randomized, double-blind, placebo-controlled, functional magnetic resonance imaging experiments involving 70 healthy male volunteers to investigate the effects of the neuropeptide oxytocin (OXT) on neural and behavioral correlates of ambivalence. We chose moral decision-making and the imagery of partner infidelity as examples to probe volitional and emotional ambivalence. In both experiments, intranasal OXT diminished neural responses in the ACC to ambivalence. Under OXT, moral dilemma vignettes also elicited a reduced activation in the orbitofrontal cortex, and the imagery of partner infidelity was rated as less arousing. Interestingly, the OXT-induced differential activation in the ACC predicted the magnitude of arousal reduction. Taken together, our findings reveal an unprecedented role of OXT in causing a domain-general decrease of neural responses to ambivalence. By alleviating emotional distress, OXT may qualify as a treatment option for psychiatric disorders with heightened ambivalence sensitivity such as schizophrenia or obsessive-compulsive disorder.

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Language(s): eng - English
 Dates: 20142015-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/scan/nsu147
PMID: 25398434
PMC: PMC4483569
Other: Epub 2014
 Degree: -

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Title: Social Cognitive and Affective Neuroscience
  Other : SCAN
  Abbreviation : Soc Cogn Affect Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 10 (7) Sequence Number: - Start / End Page: 987 - 983 Identifier: ISSN: 1749-5016
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000223760