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  fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients

Favre, P., Baciu, M., Pichat, C., Bougerol, T., & Polosan, M. (2014). fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients. Journal of Affective Disorders, 165, 182-189. doi:10.1016/j.jad.2014.04.054.

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 Creators:
Favre, Pauline1, 2, Author              
Baciu, Monica1, 2, Author
Pichat, Cédric1, 2, Author
Bougerol, Thierry3, 4, 5, 6, Author
Polosan, Mircea3, 4, 5, 6, Author
Affiliations:
1Laboratoire de Psychologie et Neurocognition (LPNC), Université Grenoble Alpes, France, ou_persistent22              
2Centre National de la Recherche Scientifique, Université Grenoble Alpes, France, ou_persistent22              
3Pôle Psychiatrie et Neurologie, Centres Experts Troubles Bipolaires, Joseph Fourier University, Grenoble, France, ou_persistent22              
4Université Grenoble Alpes, France, ou_persistent22              
5Institut national de la santé et de la recherche médicale, Université Grenoble Alpes, France, ou_persistent22              
6Centre Hospitalier Universitaire de Grenoble, France, ou_persistent22              

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Free keywords: Bipolar disorders; Euthymic; fMRI; Resting-state; Medial prefrontal cortex
 Abstract: Background Neural substrates of bipolar disorder (BD) have frequently been characterized by dysregulation of fronto-limbic networks that may persist during euthymic periods. Only a few studies have investigated euthymic bipolar patients (BP) functional connectivity at rest. The current study aims to assess resting-state functional connectivity in euthymic BP in order to identify trait abnormalities responsible for enduring mood dysregulation in these patients. Methods Medial prefrontal cortex (mPFC) functional connectivity was investigated in 20 euthymic BP and 20 healthy subjects (HS). The functional connectivity maps were compared across groups using a between-group random effect analysis. Additional region of interest (ROI) analysis focused on mPFC–amygdala functional connectivity as well as correlations between the clinical features in euthymic BP was also conducted. Results A significant difference between euthymic BP and HS was observed in terms of connectivity between the mPFC and the right dorsolateral prefrontal cortex (dlPFC). A significant negative correlation between the activity of these regions was found in HS but not in euthymic BP. In addition, euthymic BP showed greater connectivity between mPFC and right amygdala compared to HS, which was also correlated with the duration of the disease. Limitations The BP group was heterogeneous with respect to the bipolarity subtype and the medication. The robustness of results could be improved with an increased sample size. Conclusions Compared to HS, the euthymic BP showed abnormal decoupling (decreased functional connectivity) activity between mPFC–dlPFC and hyperconnectivity (increased functional connectivity) and between mPFC and amygdala. These abnormalities could underlie the pathophysiology of BD, and may deteriorate further in accordance with disease duration.

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Language(s): eng - English
 Dates: 2013-12-052014-04-232014-05-042014-08-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.jad.2014.04.054
PMID: 24882198
Other: Epub 2014
 Degree: -

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Title: Journal of Affective Disorders
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 165 Sequence Number: - Start / End Page: 182 - 189 Identifier: ISSN: 0165-0327
CoNE: https://pure.mpg.de/cone/journals/resource/954925480595