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  Modulation of fronto-limbic activity by the psychoeducation in euthymic bipolar patients: A functional MRI study

Favre, P., Baciu, M., Pichat, C., De Pourtalès, M.-A., Fredemback, B., Garcon, S., et al. (2013). Modulation of fronto-limbic activity by the psychoeducation in euthymic bipolar patients: A functional MRI study. Psychiatry Research, 214(3), 285-295. doi:10.1016/j.pscychresns.2013.07.007.

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 Creators:
Favre, Pauline1, 2, Author           
Baciu, Monica1, 2, Author
Pichat, Cédric1, Author
De Pourtalès, Marie-Atéa3, Author
Fredemback, Benjamin3, Author
Garcon, Sabrina3, Author
Bougerol, Thierry2, 3, Author
Polosan, Mircea2, 3, 4, Author
Affiliations:
1Laboratoire de Psychologie et Neurocognition (LPNC), Centre National de la Recherche Scientifique, Université Grenoble Alpes, France, ou_persistent22              
2SFR Santé et Société, Université Grenoble Alpes, France, ou_persistent22              
3Pôle Psychiatrie et Neurologie, Centres Experts Troubles Bipolaires, Joseph Fourier University, Grenoble, France, ou_persistent22              
4Brain Function and Neuromodulation, Joseph Fourier University, Grenoble, France, ou_persistent22              

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Free keywords: Bipolar disorders; fMRI; Word-face emotional Stroop; Emotional processing; Cognitive control
 Abstract: Bipolar disorders (BD) are mainly characterized by emotional and cognitive processing impairment. The cerebral substrate explaining BD impairment and the action mechanisms of therapies are not completely understood, especially for psychosocial interventions. This fMRI study aims at assessing cerebral correlates of euthymic bipolar patients (EBP) before and after psychoeducation therapy. Sixteen EBP and 16 matched healthy subjects (HS) performed a word-face emotional Stroop task in two separate fMRI sessions at 3-month interval. Between fMRI sessions, EBP underwent psychoeducation. Before psychoeducation, the comparison of EBP vs. HS in fMRI data revealed (a) significant decreased activity of cognitive control regions such as bilateral inferior and left superior frontal gyri, right insula, right fusiform gyrus and bilateral occipital gyri and (b) significant increased activity of emotion-related processing regions such as bilateral hippocampus, parahippocampal gyri and the left middle temporal gyrus. After psychoeducation, EBP showed significant clinical improvement, increased activity of inferior frontal gyri and a tendency toward decreased activity of right hippocampus and parahippocampal gyrus. These results suggest that the imbalance between cognitive control and emotion processing systems characterizing BD acute episodes may persist during euthymic periods. Moreover, this imbalance may be improved by psychoeducation, which enhances the cognitive control and modulates emotional fluctuations in EBP.

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Language(s): eng - English
 Dates: 2013-01-212013-07-252013-10-222013-12-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.pscychresns.2013.07.007
PMID: 24156926
Other: Epub 2013
 Degree: -

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Title: Psychiatry Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 214 (3) Sequence Number: - Start / End Page: 285 - 295 Identifier: ISSN: 0165-1781
CoNE: https://pure.mpg.de/cone/journals/resource/954925481603