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  Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica

Kube, M., Chernikova, T. N., Al-Ramahi, Y., Beloqui, A., Lopez-Cortez, N., Guazzaroni, M.-E., et al. (2013). Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nature Communications, 4: 4:2156. doi:10.1038/ncomms3156.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-B06B-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-B06C-4
Genre: Journal Article

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 Creators:
Kube, Michael, Author
Chernikova, Tatyana N., Author
Al-Ramahi, Yamal, Author
Beloqui, Ana, Author
Lopez-Cortez, Nieves, Author
Guazzaroni, María-Eugenia, Author
Heipieper, Hermann J., Author
Klages, Sven1, Author              
Kotsyurbenko, Oleg R., Author
Langer, Ines, Author
Nechitaylo, Taras Y., Author
Lünsdorf, Heinrich, Author
Fernández, Marisol, Author
Juárez, Silvia, Author
Ciordia, Sergio, Author
Singer, Alexander, Author
Kagan, Olga, Author
Egorova, Olga, Author
Alain Petit, Pierre, Author
Stogios, Peter, Author
Kim, Youngchang, AuthorTchigvintsev, Anatoli, AuthorFlick, Robert, AuthorDenaro, Renata, AuthorGenovese, Maria, AuthorAlbar, Juan P., AuthorReva, Oleg N., AuthorMartínez-Gomariz, Montserrat, AuthorTran, Hai, AuthorFerrer, Manuel, AuthorSavchenko, Alexei, AuthorYakunin, Alexander F., AuthorYakimov, Michail M., AuthorGolyshina, Olga V., AuthorReinhardt, Richard, AuthorGolyshin, Peter N., Author more..
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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Free keywords: Biological sciences Genetics Microbiology
 Abstract: Ubiquitous bacteria from the genus Oleispira drive oil degradation in the largest environment on Earth, the cold and deep sea. Here we report the genome sequence of Oleispira antarctica and show that compared with Alcanivorax borkumensis—the paradigm of mesophilic hydrocarbonoclastic bacteria—O. antarctica has a larger genome that has witnessed massive gene-transfer events. We identify an array of alkane monooxygenases, osmoprotectants, siderophores and micronutrient-scavenging pathways. We also show that at low temperatures, the main protein-folding machine Cpn60 functions as a single heptameric barrel that uses larger proteins as substrates compared with the classical double-barrel structure observed at higher temperatures. With 11 protein crystal structures, we further report the largest set of structures from one psychrotolerant organism. The most common structural feature is an increased content of surface-exposed negatively charged residues compared to their mesophilic counterparts. Our findings are relevant in the context of microbial cold-adaptation mechanisms and the development of strategies for oil-spill mitigation in cold environments.

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Language(s): eng - English
 Dates: 2013-06-182013-07-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 23877221
DOI: 10.1038/ncomms3156
 Degree: -

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Title: Nature Communications
Source Genre: Journal
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Affiliations:
Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 4 Sequence Number: 4:2156 Start / End Page: - Identifier: Other: Nat Commun
Other: Nat Commun
ISSN: 2041-1723