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  Sequential karyotyping in Burkitt lymphoma reveals a linear clonal evolution with increase in karyotype complexity and a high frequency of recurrent secondary aberrations

Aukema, S. M., Theil, L., Rohde, M., Bauer, B., Bradtke, J., Burkhardt, B., et al. (2015). Sequential karyotyping in Burkitt lymphoma reveals a linear clonal evolution with increase in karyotype complexity and a high frequency of recurrent secondary aberrations. British Journal of Haematology, 170(6), 814-825. doi:10.1111/bjh.13501.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-B2EB-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-5135-F
Genre: Journal Article

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 Creators:
Aukema, Sietse M., Author
Theil, Laura, Author
Rohde, Marius, Author
Bauer, Benedikt1, Author              
Bradtke, Jutta, Author
Burkhardt, Birgit, Author
Bonn, Bettina R., Author
Claviez, Alexander, Author
Gattenlöhner, Stefan, Author
Makarova, Olga, Author
Nagel, Inga, Author
Oschlies, Ilske, Author
Pott, Christiane, Author
Szczepanowski, Monika, Author
Traulsen, Arne1, Author              
Kluin, Philip M., Author
Klapper, Wolfram, Author
Siebert, Reiner, Author
Penas, Eva M. Murga, Author
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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Free keywords: Burkitt lymphoma; clonal evolution; MYC; relapse; progression
 Abstract: Typical Burkitt lymphoma is characterized by an IG-MYC translocation and overall low genomic complexity. Clinically, Burkitt lymphoma has a favourable prognosis with very few relapses. However, the few patients experiencing disease progression and/or relapse have a dismal outcome. Here we report cytogenetic findings of seven cases of Burkitt lymphoma in which sequential karyotyping was performed at time of diagnosis and/or disease progression/relapse(s). After case selection, karyotype re-review and additional molecular analyses were performed in six paediatric cases, treated in Berlin-Frankfurt-Münster-Non-Hodgkin lymphoma study group trials, and one additional adult patient. Moreover, we analysed 18 cases of Burkitt lymphoma from the Mitelman database in which sequential karyotyping was performed. Our findings show secondary karyotypes to have a significant increase in load of cytogenetic aberrations with a mean number of 2, 5 and 8 aberrations for primary, secondary and third investigations. Importantly, this increase in karyotype complexity seemed to result from recurrent secondary chromosomal changes involving mainly trisomy 21, gains of 1q and 7q, losses of 6q, 11q, 13q, and 17p. In addition, our findings indicate a linear clonal evolution to be the predominant manner of cytogenetic evolution. Our data may provide a biological framework for the dismal outcome of progressive and relapsing Burkitt lymphoma.

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Language(s): eng - English
 Dates: 2014-10-282015-04-102015-06-242015-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/bjh.13501
 Degree: -

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Title: British Journal of Haematology
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Scientific Publications
Pages: - Volume / Issue: 170 (6) Sequence Number: - Start / End Page: 814 - 825 Identifier: ISSN: 0007-1048 (print)
ISSN: 1365-2141 (online)
CoNE: /journals/resource/954925386149