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  Aberrant salience is related to dysfunctional self-referential processing in psychosis

Pankow, A., Katthagen, T., Diner, S., Deserno, L., Boehme, R., Kathmann, N., et al. (2016). Aberrant salience is related to dysfunctional self-referential processing in psychosis. Schizophrenia Bulletin, 42(1), 67-76. doi:10.1093/schbul/sbv098.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C016-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19E4-0
Genre: Journal Article

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 Creators:
Pankow, Anne1, Author
Katthagen, Teresa1, Author
Diner, Sarah1, Author
Deserno, Lorenz1, 2, 3, Author              
Boehme, Rebecca1, Author
Kathmann, Norbert4, Author
Gleich, Tobias1, Author
Gaebler, Michael1, 3, 5, Author              
Walter, Henrik1, Author
Heinz, Andreas1, Author
Schlagenhauf, Florian1, 3, Author              
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
5Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Psychosis; Salience; vmPFC; Self-referential processing; fMRI; Psychosis continuum
 Abstract: Background. A dysfunctional differentiation between self-relevant and irrelevant information may affect the perception of environmental stimuli as abnormally salient. The aberrant salience hypothesis assumes that positive symptoms arise from an attribution of salience to irrelevant stimuli accompanied by the feeling of self-relevance. Self-referential processing relies on the activation of cortical midline structures which was demonstrated to be impaired in psychosis. We investigated the neural correlates of self-referential processing, aberrant salience attribution, and the relationship between these 2 measures across the psychosis continuum. Methods. Twenty-nine schizophrenia patients, 24 healthy individuals with subclinical delusional ideation, and 50 healthy individuals participated in this study. Aberrant salience was assessed behaviorally in terms of reaction times to task irrelevant cues. Participants performed a self-reference task during fMRI in which they had to apply neutral trait words to them or to a public figure. The correlation between self-referential processing and aberrant salience attribution was tested. Results. Schizophrenia patients displayed increased aberrant salience attribution compared with healthy controls and individuals with subclinical delusional ideation, while the latter exhibited intermediate aberrant salience scores. In the self-reference task, schizophrenia patients showed reduced activation in the ventromedial prefrontal cortex (vmPFC), but individuals with subclinical delusional ideation did not differ from healthy controls. In schizophrenia patients, vmPFC activation correlated negatively with implicit aberrant salience attribution. Conclusions. Higher aberrant salience attribution in schizophrenia patients is related to reduced vmPFC activation during self-referential judgments suggesting that aberrant relevance coding is reflected in decreased neural self-referential processing as well as in aberrant salience attribution.

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Language(s): eng - English
 Dates: 2015-06-292015-07-202016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/schbul/sbv098
PMID: 26194892
PMC: PMC4681553
Other: Epub 2015
 Degree: -

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Title: Schizophrenia Bulletin
  Other : Schizophr. Bull.
Source Genre: Journal
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Publ. Info: Rockville, MD : U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration
Pages: - Volume / Issue: 42 (1) Sequence Number: - Start / End Page: 67 - 76 Identifier: ISSN: 0586-7614
CoNE: /journals/resource/954925532975