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  Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype

Männel, C., Meyer, L., Wilcke, A., Boltze, J., Kirsten, H., & Friederici, A. D. (2015). Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype. Cortex, 71, 291-305. doi:10.1016/j.cortex.2015.06.029.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C248-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7C09-9
Genre: Journal Article

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 Creators:
Männel, Claudia1, Author              
Meyer, Lars1, Author              
Wilcke, Arndt2, 3, Author
Boltze, Johannes2, 3, 4, Author
Kirsten, Holger2, 3, 5, Author
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
3Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Germany, ou_persistent22              
4Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              
5Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Developmental dyslexia; Genetic risk; Gray matter; Posterior temporal cortex; Working memory
 Abstract: Developmental dyslexia, a severe impairment of literacy acquisition, is known to have a neurological basis and a strong genetic background. However, effects of individual genetic variations on dyslexia-associated deficits are only moderate and call for the assessment of the genotype’s impact on mediating neuro-endophenotypes by the imaging genetics approach. Using voxel-based morphometry (VBM) in German participants with and without dyslexia, we investigated gray matter changes and their association with impaired phonological processing, such as reduced verbal working memory. These endophenotypical alterations were, together with dyslexia-associated genetic variations, examined on their suitability as potential predictors of dyslexia. We identified two gray matter clusters in the left posterior temporal cortex related to verbal working memory capacity. Regional cluster differences correlated with genetic risk variants in TNFRSF1B. High-genetic-risk participants exhibit a structural predominance of auditory-association areas relative to auditory-sensory areas, which may partly compensate for deficient early auditory-sensory processing stages of verbal working memory. The reverse regional predominance observed in low-genetic-risk participants may in turn reflect reliance on these early auditory-sensory processing stages. Logistic regression analysis further supported that regional gray matter differences and genetic risk interact in the prediction of individuals' diagnostic status: With increasing genetic risk, the working-memory related structural predominance of auditory-association areas relative to auditory-sensory areas classifies participants with dyslexia versus control participants. Focusing on phonological deficits in dyslexia, our findings suggest endophenotypical changes in the left posterior temporal cortex could comprise novel pathomechanisms for verbal working memory-related processes translating TNFRSF1B genotype into the dyslexia phenotype.

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Language(s): eng - English
 Dates: 2015-04-282014-09-252015-06-022015-07-222015-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cortex.2015.06.029
PMID: 26283516
Other: Epub 2015
 Degree: -

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Title: Cortex
  Other : Cortex
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 71 Sequence Number: - Start / End Page: 291 - 305 Identifier: ISSN: 0010-9452
CoNE: /journals/resource/954925393344