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  Cytoplasmic sensing of viral nucleic acids

Habjan, M., & Pichlmair, A. (2015). Cytoplasmic sensing of viral nucleic acids. CURRENT OPINION IN VIROLOGY, 11( Special Issue: Viral pathogenesis • Preventive and therapeutic vaccines), 31-37. doi:10.1016/j.coviro.2015.01.012.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-D1B1-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-D1B2-B
Genre: Journal Article

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 Creators:
Habjan, Matthias1, Author           
Pichlmair, Andreas1, Author           
Affiliations:
1Pichlmair, Andreas / Innate Immunity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565166              

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Free keywords: INNATE IMMUNE SENSOR; CYTOSOLIC DNA SENSOR; IFIT FAMILY-MEMBERS; DOUBLE-STRANDED-RNA; GMP-AMP SYNTHASE; INDUCIBLE GENE-I; RIG-I; MESSENGER-RNA; ANTIVIRAL PROTEIN; SIGNAL-ACTIVATION
 Abstract: Viruses are the most abundant pathogens on earth. A fine-tuned framework of intervening pathways is in place in mammalian cells to orchestrate the cellular defence against these pathogens. Key for this system is sensor proteins that recognise specific features associated with nucleic acids of incoming viruses. Here we review the current knowledge on cytoplasmic sensors for viral nucleic acids. These sensors induce expression of cytokines, affect cellular functions required for virus replication and directly target viral nucleic acids through degradation or sequestration. Their ability to respond to a given nucleic acid is based on both the differential specificity of the individual proteins and the downstream signalling or adaptor proteins. The cooperation of these multiple proteins and pathways plays a key role in inducing successful immunity against virus infections.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000356547000007
DOI: 10.1016/j.coviro.2015.01.012
 Degree: -

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Title: CURRENT OPINION IN VIROLOGY
Source Genre: Journal
 Creator(s):
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Publ. Info: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND : ELSEVIER SCI LTD
Pages: - Volume / Issue: 11 ( Special Issue: Viral pathogenesis • Preventive and therapeutic vaccines) Sequence Number: - Start / End Page: 31 - 37 Identifier: ISSN: 1879-6257