English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The subthalamic nucleus during decision-making with multiple alternatives

Keuken, M. C., van Maanen, L., Bogacz, R., Schäfer, A., Neumann, J., Turner, R., et al. (2015). The subthalamic nucleus during decision-making with multiple alternatives. Human Brain Mapping, 36(10), 4041-4052. doi:10.1002/hbm.22896.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-D444-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-792C-5
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Keuken, Max C.1, 2, Author              
van Maanen, Leendert2, Author
Bogacz, Rafal3, Author
Schäfer, Andreas4, Author              
Neumann, Jane5, Author              
Turner, Robert6, Author              
Forstmann, Birte U.2, Author              
Affiliations:
1MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634548              
2Amsterdam Brain and Cognition (ABC), University of Amsterdam, the Netherlands, ou_persistent22              
3Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

Content

show
hide
Free keywords: Decision-making; Basal ganglia; Computational modeling; Ultrahigh field magnetic resonance imaging; Functional magnetic resonance imaging; Diffusion weighted imaging
 Abstract: Several prominent neurocomputational models predict that an increase of choice alternatives is modulated by increased activity in the subthalamic nucleus (STN). In turn, increased STN activity allows prolonged accumulation of information. At the same time, areas in the medial frontal cortex such as the anterior cingulate cortex (ACC) and the pre-SMA are hypothesized to influence the information processing in the STN. This study set out to test concrete predictions of STN activity in multiple-alternative decision-making using a multimodal combination of 7 Tesla structural and functional Magnetic Resonance Imaging, and ancestral graph (AG) modeling. The results are in line with the predictions in that increased STN activity was found with an increasing amount of choice alternatives. In addition, our study shows that activity in the ACC is correlated with activity in the STN without directly modulating it. This result sheds new light on the information processing streams between medial frontal cortex and the basal ganglia.

Details

show
hide
Language(s): eng - English
 Dates: 2015-06-182014-12-232015-06-262015-07-152015-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.22896
PMID: 26178078
PMC: PMC4896390
Other: Epub 2015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 36 (10) Sequence Number: - Start / End Page: 4041 - 4052 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686