English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Snapshot: Spliceosome dynamics III.

Wahl, M. C., & Lührmann, R. (2015). Snapshot: Spliceosome dynamics III. Cell, 162(3), 690-690.e1. doi:10.1016/j.cell.2015.07.033.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F4D5-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-9B0E-1
Genre: Journal Article

Files

show Files
hide Files
:
2174992.pdf (Publisher version), 165KB
 
File Permalink:
-
Name:
2174992.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Wahl, M. C., Author
Lührmann, R.1, Author              
Affiliations:
1Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578576              

Content

show
hide
Free keywords: -
 Abstract: The complex compositional and conformational dynamics of spliceosomes required for regulated splicing are prone to malfunction when mutations affect splicing factors or cis-acting regulatory sequences. Indeed, many such mutations have been linked to heritable diseases or malignancies in humans. Small molecule modulators and antisense oligonucleotides or analogs harbor great potential for therapies and several substances that can modulate splicing events have entered clinical trials.

Details

show
hide
Language(s): eng - English
 Dates: 2015-07-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cell.2015.07.033
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 162 (3) Sequence Number: - Start / End Page: 690 - 690.e1 Identifier: -