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  Lost in translocation: The functions of the 18-kD translocator protein.

Gut, P., Zweckstetter, M., & Banati, R. B. (2015). Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism, 26(7), 349-356. doi:10.1016/j.tem.2015.04.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-135C-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-2E60-6
Genre: Journal Article

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2175600.pdf (Publisher version), 694KB
 
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 Creators:
Gut, P., Author
Zweckstetter, M.1, Author              
Banati, R. B., Author
Affiliations:
1Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              

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Free keywords: neuroinflammation; neuroimaging; peripheral benzodiazepine receptor; heme metabolism; REV-ERB alpha; mitochondrial permeability transition pore; cholesterol
 Abstract: Research spanning nearly four decades has assigned to the translocator protein (18 kDa) (TSPO) a critical role, among others, in the mitochondrial import of cholesterol, the subsequent steps of (neuro)steroid production, and systemic endocrine regulation, with implications for the pathophysiology of immune, inflammatory, neurodegenerative, and psychiatric as well as neoplastic diseases. Recent knockout studies in mice unexpectedly report normal or latent phenotypes, raising doubts about the protein's role in steroidogenesis and other previously postulated functions and challenging the validity of earlier data on the selectivity of TSPO-binding drugs. Here we provide a synthesis of the current debate from a structural and molecular biology perspective, discuss the limits of inference in loss-of-function (gene knockout) studies, and suggest new functions of TSPO.

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Language(s): eng - English
 Dates: 2015-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tem.2015.04.001
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Title: Trends in Endocrinology and Metabolism
Source Genre: Journal
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Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 349 - 356 Identifier: -