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  Compound exocytosis and cumulative degranulation by eosinophils and their role in parasite killing.

Scepek, S., Moqbel, R., & Lindau, M. (1994). Compound exocytosis and cumulative degranulation by eosinophils and their role in parasite killing. Parasitology Today, 10(7), 276-278. doi:10.1016/0169-4758(94)90146-5.

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Scepek, S., Author
Moqbel, R., Author
Lindau, M.1, Author              
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1Research Group of Nanoscale Cell Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1832294              

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 Abstract: The killing of metazoan parasitic larvae by eosinophils occurs following cell adhesion and the secretion o f their cytotoxic proteins onto the surface o f these targets. In eosinophils, as in mast cells and neutrophils, stimulus-secretion coupling is mediated by GTP-binding proteins. In this article, Susanne Scepek Redwon Moqbel and Manfred Lindou summarize recent results indicating that the granule-fusion events activated by GTP-binding proteins lead to compound exocytosis and cumulative fusion. They propose that these exocytotic processes, following contact with opsonized larvae, may direct secretion to a restricted space defined by the site o f contact Such a focused release may be essential for effective targeting in parasite killing, thus preventing uncontrolled random diffusion of the secreted cytotoxic proteins with the possible undesirable consequences of damage to intact host tissue.

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Language(s): eng - English
 Dates: 1994-07
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0169-4758(94)90146-5
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Title: Parasitology Today
Source Genre: Journal
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Pages: - Volume / Issue: 10 (7) Sequence Number: - Start / End Page: 276 - 278 Identifier: -