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  Identifying neural correlates of visual consciousness with ALE meta-analyses

Bisenius, S., Trapp, S., Neumann, J., & Schroeter, M. L. (2015). Identifying neural correlates of visual consciousness with ALE meta-analyses. NeuroImage, 122, 177-187. doi:10.1016/j.neuroimage.2015.07.070.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-16A1-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7C07-B
Genre: Journal Article

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 Creators:
Bisenius, Sandrine1, Author              
Trapp, Sabrina1, Author              
Neumann, Jane1, 2, Author              
Schroeter, Matthias L.1, 3, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Consciousness; fMRI; NCC; Global workspace; Perception; Meta-analysis
 Abstract: Neural correlates of consciousness (NCC) have been a topic of study for nearly two decades. In functional imaging studies, several regions have been proposed to constitute possible candidates for NCC, but as of yet, no quantitative summary of the literature on NCC has been done. The question whether single (striate or extrastriate) regions or a network consisting of extrastriate areas that project directly to fronto-parietal regions are necessary and sufficient neural correlates for visual consciousness is still highly debated [e.g., Rees et al., 2002, Nat Rev. Neurosci 3, 261–270; Tong, 2003, Nat Rev. Neurosci 4, 219–229]. The aim of this work was to elucidate this issue and give a synopsis of the present state of the art by conducting systematic and quantitative meta-analyses across functional magnetic resonance imaging (fMRI) studies using several standard paradigms for conscious visual perception. In these paradigms, consciousness is operationalized via perceptual changes, while the visual stimulus remains invariant. An activation likelihood estimation (ALE) meta-analysis was performed, representing the best approach for voxel-wise meta-analyses to date. In addition to computing a meta-analysis across all paradigms, separate meta-analyses on bistable perception and masking paradigms were conducted to assess whether these paradigms show common or different NCC. For the overall meta-analysis, we found significant clusters of activation in inferior and middle occipital gyrus; fusiform gyrus; inferior temporal gyrus; caudate nucleus; insula; inferior, middle, and superior frontal gyri; precuneus; as well as in inferior and superior parietal lobules. These results suggest a subcortical-extrastriate-fronto-parietal network rather than a single region that constitutes the necessary NCC. The results of our exploratory paradigm-specific meta-analyses suggest that this subcortical-extrastriate-fronto-parietal network might be differentially activated as a function of the paradigms used to probe for NCC.

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Language(s): eng - English
 Dates: 2014-08-312015-07-272015-08-012015-11-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.07.070
PMID: 26241685
Other: Epub 2015
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 122 Sequence Number: - Start / End Page: 177 - 187 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166