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  Self-Localizing Stabilized Mega-Pixel Picoliter Arrays with Size-Exclusion Sorting Capabilities

Zarrine-Afsar, A., Müller, C., Talbot, F. O., & Miller, R. J. D. (2011). Self-Localizing Stabilized Mega-Pixel Picoliter Arrays with Size-Exclusion Sorting Capabilities. Analytical Chemistry, 83(3), 767-773. doi:10.1021/ac1021024.

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http://dx.doi.org/10.1021/ac1021024 (Publisher version)
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 Creators:
Zarrine-Afsar, Arash1, 2, 3, Author              
Müller, Christina1, 2, 3, Author              
Talbot, Francis O.1, 2, 3, Author              
Miller, R. J. Dwayne1, 2, 3, Author              
Affiliations:
1Atomically Resolved Structural Dynamics Division, Max Planck Research Department for Structural Dynamics, Department of Physics, University of Hamburg, External Organizations, ou_2173636              
2Centre for Free Electron Laser Science, DESY, Notkestrasse 85, Hamburg, 22607 Germany, ou_persistent22              
3Departments of Chemistry and Physics, Institute for Optical Sciences, 80 St. George Street, University of Toronto, Toronto, ON, Canada M5S-3H6, ou_persistent22              

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 Abstract: We report on a liquid self-localizing process capable of producing Mega-pixel arrays of picoliter volumes on a 1 cm2 area, within seconds, for high throughput sampling. The chip is based on principles of spatially varying wetting and stabilization. The key is to develop differential surface contact regions, which lead to both localization of the solution and increasing the surface adsorption energy to further pin the liquid to the surface, as highlighted by other studies. By exploiting surface roughness for enhanced wettability, we demonstrate wetting of wells with the aspect ratio of 100. The high precision of reactive ion etching (RIE) of silicon substrates allows for an extremely reproducible method of preparing the array of identical well structures and increased contact area to increase surface adsorption in the wells. “Dynamic wetting” is then readily achieved through inducing contact line instability by simply moving a drop of liquid on the top surface of the array. Liquid samples self-localize into the array pattern with the associated liquid flow leading to self-localization of suspended particles or analyte. The resulting picoliter volumes are both spatially ordered and stable for long periods of time, even for such small volumes, to permit selective measurements of the contents. This development will be particularly important in the assembly of the massive amounts of crystalline particles needed for atomically resolved structural dynamics using the latest advances in high number density electron and X-ray sources.

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Language(s): eng - English
 Dates: 2010-08-102010-12-022010-12-212011-02-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ac1021024
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Title: Analytical Chemistry
  Abbreviation : Anal. Chem.
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 83 (3) Sequence Number: - Start / End Page: 767 - 773 Identifier: Other: 0003-2700
CoNE: https://pure.mpg.de/cone/journals/resource/111032812862552