English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Octacalcium phosphate - a metastable mineral phase controls the evolution of scaffold forming proteins

Pompe, W., Worch, H., Habraken, W. J. E. M., Simon, P., Kniep, R., Ehrlich, H., et al. (2015). Octacalcium phosphate - a metastable mineral phase controls the evolution of scaffold forming proteins. Journal of Materials Chemistry B, 3(26), 5318-5329. doi:10.1039/c5tb00673b.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-2879-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-287A-F
Genre: Journal Article

Files

show Files
hide Files
:
2176672.pdf (Publisher version), 3MB
 
File Permalink:
-
Name:
2176672.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2176672_supp.pdf (Supplementary material), 527KB
Name:
2176672_supp.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Pompe, Wolfgang1, Author
Worch, Hartmut1, Author
Habraken, W. J. E. M.2, Author              
Simon, Paul1, Author
Kniep, Rüdiger1, Author
Ehrlich, Hermann1, Author
Paufler, Peter1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

Content

show
hide
Free keywords: -
 Abstract: The molecular structure of collagen type 1 can be understood as the result of evolutionary selection in the process of formation of calcium phosphate based biocomposites acting as load bearing components in living organisms. The evolutionary selection fulfills the principle of 'survival of the fittest' in a particular biological environment. Disk-like post-nucleation complexes of Ca-2(HPO4)(3)(2-) organized in ribbon-like assemblies in the metastable octacalcium phosphate (OCP) phase, and Ca-3 triangles in the stable HAP phase had formed the crystallographic motifs in this selection process. The rotational as well as the translational symmetry of the major tropocollagen (TC) helix agree nearly perfectly with the corresponding symmetries of the OCP structure. The sequence of (Gly-X-Y) motifs of the three a chains constituting the TC molecule enables an optimized structural fit for the nucleation of Ca-3 triangles, the directed growth of nanostructured OCP, and the subsequent formation of hydroxyapatite (HAP) in collagen macrofibrils by a topotaxial transition. The known connection between genetic defects of collagen type 1 and Osteogenesis imperfecta should motivate the search for similar dependences of other bone diseases on a disturbed molecular structure of collagen on the genetic scale.

Details

show
hide
Language(s): eng - English
 Dates: 2015-06-012015-06-28
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000356964700022
DOI: 10.1039/c5tb00673b
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Materials Chemistry B
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 3 (26) Sequence Number: - Start / End Page: 5318 - 5329 Identifier: ISSN: 2050-750X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-750X