ausblenden:
Schlagwörter:
diet-induced obesity, Park7, DJ-1 Mice, Neurodegeneration, High-fat diet
Zusammenfassung:
DJ-1 constitutes a ubiquitously expressed, oxidative stress-responsive
protein with multiple functions. DJ-1 emerged as a candidate from our
previous proteome analysis investigating alterations in the hypothalamus
in three mouse strains differing in their susceptibility to diet-induced
obesity (DID). Validation studies demonstrated a high-fat diet
(HFD)-induced shift in the DJ-1 isoform pattern in the hypothalamus and
several other tissues of mice. Others found HFD-induced alterations in
DJ-1 protein abundance in adipose tissue and pancreatic islets in
wild-type rodents. Here, we investigated the gene-diet interaction by
challenging Dj-(-/-) mice with a HFD. We demonstrate that the
development of diet-induced obesity (DIO)Dj-1(-/-) mice is according to
wild-type mice with the exception of transient higher gains in fat mass
at the expense of lean mass after 14 weeks of feeding. (C) 2015 Elsevier
Inc. All rights reserved.
