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Abstract:
A large body of evidence describes the long term impact of stress on a
number of biological systems and with it associated adverse health
outcomes. This article will discuss the epigenetic mechanisms of the
embedding of these long term changes, the differences in these
mechanisms depending on the type and timing of stress exposure,
including transgenerational effects as well as differences in the
mechanisms for tissue specific versus more global epigenetic changes. A
mechanistic understanding of the long term epigenetic consequences of
stress may allow novel, targeted intervention and prevention strategies
for psychiatric and other stress-associated disorders.
