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  MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene

Nischwitz, S., Wolf, C., Andlauer, T., Czamara, D., Zettl, U. K., Rieckmann, P., et al. (2015). MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene. JOURNAL OF NEUROIMMUNOLOGY, 279, 46-49. doi:10.1016/j.jneuroim.2015.01.008.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-F54F-D Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-F550-7
Genre: Journal Article

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 Creators:
Nischwitz, S.1, Author           
Wolf, C.1, Author           
Andlauer, T.F.M.1, Author           
Czamara, D.1, Author           
Zettl, U. K.2, Author
Rieckmann, P.2, Author
Buck, D.2, Author
Ising, M.1, Author           
Bettecken, T.1, Author           
Mueller-Myhsok, B.1, Author           
Weber, F.1, Author           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2external, ou_persistent22              

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Free keywords: Multiple sclerosis, MMP9, Susceptibility, GWAS, Imputation
 Abstract: Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2 Mbp up-and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect. (C) 2015 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2015-02-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000350088300009
DOI: 10.1016/j.jneuroim.2015.01.008
 Degree: -

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Title: JOURNAL OF NEUROIMMUNOLOGY
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 279 Sequence Number: - Start / End Page: 46 - 49 Identifier: ISSN: 0165-5728