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  A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser

Böttcher, A., Clauditz, T. S., Knecht, R., Kucher, S., Wöllmer, W., Wilczak, W., et al. (2013). A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser. The Laryngoscope, 123(11), 2770-2775. doi:10.1002/lary.24124.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-1E21-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-E281-7
Genre: Journal Article

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http://dx.doi.org/10.1002/lary.24124 (Publisher version)
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 Creators:
Böttcher, Arne1, Author
Clauditz, Till S.2, Author
Knecht, Rainald1, Author
Kucher, Stanislav1, Author
Wöllmer, Wolfgang1, Author
Wilczak, Waldemar2, Author
Krötz, Peter3, 4, Author              
Jowett, Nathan5, Author
Dalchow, Carsten V.1, Author
Münscher, Adrian1, Author
Miller, R. J. Dwayne3, Author              
Affiliations:
1Department of Otorhinolaryngology, Head and Neck Surgery, Max Planck Research Department for Structural Dynamics, University of Hamburg, Hamburg, Germany, ou_persistent22              
2Department of Pathology, Max Planck Research Department for Structural Dynamics, University of Hamburg, Hamburg, Germany, ou_persistent22              
3Atomically Resolved Structural Dynamics Division, Max Planck Research Department for Structural Dynamics, Department of Physics, University of Hamburg, External Organizations, ou_2173636              
4International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              
5Department of Otolaryngology–Head and Neck Surgery, McGill University, Montreal, Quebec, Canada, ou_persistent22              

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Free keywords: Larynx surgery; laser; PIRL; histology; damage zone; laryngeal surgery; CO2
 Abstract: Objectives/Hypothesis: Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to drive ablation on timescales faster than energy transport to minimize collateral damage to adjacent cells. Study Design: Animal cadaver study. Methods: Cuts in porcine laryngeal epithelium, lamina propria, and cartilage were made using PIRL and carbon dioxide (CO2) laser. Lateral damage zones and cutting gaps were histologically compared. Results: The mean widths of epithelial (8.5 μm), subepithelial (10.9 μm), and cartilage damage zones (8.1 μm) were significantly lower for cuts made by PIRL compared with CO2 laser (p < 0.001). Mean cutting gaps in vocal fold (174.7 μm) and epiglottic cartilage (56.3 μm) were significantly narrower for cuts made by PIRL compared with CO2 laser (P < 0.01, P < 0.05). Conclusion: PIRL ablation demonstrates superiority over CO2 laser in cutting precision with less collateral tissue damage.

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Language(s): eng - English
 Dates: 2013-03-052013-05-132013-11
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/lary.24124
 Degree: -

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Title: The Laryngoscope
Source Genre: Journal
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Publ. Info: Hoboken, NJ : Wiley-Blackwell
Pages: - Volume / Issue: 123 (11) Sequence Number: - Start / End Page: 2770 - 2775 Identifier: ISSN: 1531-4995
CoNE: https://pure.mpg.de/cone/journals/resource/1531-4995