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  Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons

Buran, B., Strenzke, N., Neef, A., Gundelfinger, E., Moser, T., & Liberman, M. C. (2010). Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. The Journal of Neuroscience, 30, 7587-7597. doi:10.1523/JNEUROSCI.0389-10.2010.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-1253-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-1254-E
Genre: Journal Article

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 Creators:
Buran, Brad, Author
Strenzke, Nicola, Author
Neef, Andreas1, Author              
Gundelfinger, Eckart, Author
Moser, Tobias2, Author
Liberman, M Charles, Author
Affiliations:
1Research Group Theoretical Neurophysics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063289              
2Max Planck Society, ou_persistent13              

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 Abstract: Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been implicated in the vesicle-pool dynamics of synaptic transmission. To elucidate ribbon function, we characterized the response properties of single auditory nerve fibers in mice lacking Bassoon, a scaffolding protein involved in anchoring ribbons to the membrane. In bassoon mutants, immunohistochemistry showed that fewer than 3% of the hair cells’ afferent synapses retained anchored ribbons. Auditory nerve fibers from mutants had normal threshold, dynamic range, and postonset adaptation in response to tone bursts, and they were able to phase lock with normal precision to amplitude-modulated tones. However, spontaneous and sound-evoked discharge rates were reduced, and the reliability of spikes, particularly at stimulus onset, was significantly degraded as shown by an increased variance of first-spike latencies. Modeling based on in vitro studies of normal and mutant hair cells links these findings to reduced release rates at the synapse. The degradation of response reliability in these mutants suggests that the ribbon and/or Bassoon normally facilitate high rates of exocytosis and that its absence significantly compromises the temporal resolving power of the auditory system.

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Language(s): eng - English
 Dates: 2010-06-02
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 576044
DOI: 10.1523/JNEUROSCI.0389-10.2010
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Title: The Journal of Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 30 Sequence Number: - Start / End Page: 7587 - 7597 Identifier: -